miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells

الملخص EN

As an evolutionarily conserved metabolic process, autophagy is involved in the process of atherosclerosis (AS).

MicroRNA-155 (miR-155), a multifunctional miRNA, plays an important role in many physiological and pathological conditions, including AS and autophagy.

However, the effect of miR-155 on the regulation of autophagy in endothelial cells has not been reported to date.

Therefore, the objective of our study was to investigate the role of miR-155 in autophagy induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells (HUVECs).

Our results demonstrated that ox-LDL induced autophagy in HUVECs and increased the expression of miR-155 significantly.

Overexpression of miR-155 improved autophagic activity, whereas low expression of miR-155 inhibited autophagic activity.

Therefore, the data demonstrated that miR-155 has a modulating effect on the autophagy of vascular endothelial cells.