![](/images/graphics-bg.png)
Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes
المؤلفون المشاركون
Axelgaard, Esben
Thiel, Steffen
Haxha, Saranda
Hansen, Troels Krarup
Østergaard, Jakob Appel
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes.
MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway.
In two recent animal studies, we have shown that autoreactivity of MBL is increased in the kidney in diabetic nephropathy.
We hypothesize that long-term exposure to uncontrolled high blood glucose in diabetes may mediate formation of neoepitopes in several tissues and that MBL is able to recognize these structures and thus activate the lectin pathway.
To test this hypothesis, we induced diabetes by injection of low-dose streptozotocin in MBL double-knockout (MBL/DKO) mice.
Development of diabetes was followed by measurements of blood glucose and urine albumin-to-creatinine ratio.
Fluorophore-labelled recombinant MBL was injected intravenously in diabetic and nondiabetic mice followed by ex vivo imaging of several organs.
We observed that MBL accumulated in the heart, liver, brain, lung, pancreas, and intestines of diabetic mice.
We furthermore detected increased systemic complement activation after administration of MBL, thus indicating MBL-mediated systemic complement activation in these animals.
These new findings indicate a global role of MBL during late diabetes-mediated vascular complications in various tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Axelgaard, Esben& Østergaard, Jakob Appel& Haxha, Saranda& Thiel, Steffen& Hansen, Troels Krarup. 2017. Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Axelgaard, Esben…[et al.]. Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1188823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Axelgaard, Esben& Østergaard, Jakob Appel& Haxha, Saranda& Thiel, Steffen& Hansen, Troels Krarup. Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1188823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)