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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1CX3CR1 Signaling in Human Placental Circulation
المؤلفون المشاركون
Tarnowski, Wieslaw
Szewczyk, Grzegorz
Szukiewicz, Dariusz
Bachanek, Michal
Trojanowski, Seweryn
Braksator, Wojciech
Pyzlak, Michal
Stangret, Aleksandra
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-01
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Hyperglycemia-induced hyperactivity of chemokine CX3CL1 (fractalkine) occurs in the human placenta.
Anti-inflammatory/antioxidant activities of resveratrol (3,5,4′-trihydroxy-trans-stilbene) are related to the modulation of chemokine CX3CL1 and its receptor, CX3CR1, signaling pathways.
We examined the influence of high glucose (25 mmol/L glucose; HG group; N=36) on resveratrol-mediated effects on CX3CL1 and TNF-α production by the placental lobule, CX3CR1 expression and contents of CX3CR1, TNF-α receptor 1 (TNFR1), and NF-κB proteins in placental tissue.
The placental lobules perfused under normoglycemic conditions formed the control NG group (N=36).
Resveratrol (50 and 100 μM; subgroups B and C) administered into the perfusion fluid lowered the production of both CX3CL1 and TNF-α.
The reductions in CX3CL1 levels were more evident in the NG group.
CX3CR1 expression was significantly higher in the NG subgroups B and C compared to the HG subgroups B and C (385.2 and 426.5% versus 199.3 and 282.4%, resp.).
An increase in CX3CR1 protein content in placental lysates was observed in the NG subgroups B and C.
Also, resveratrol significantly decreased NF-κBp65 protein content only in the NG group, not affecting hyperglycemia-elicited TNFR1 upregulation.
In conclusion, euglycemia assures optimal effects of resveratrol pertaining to CX3CL1/CX3CR1 signaling in the placenta.
Future studies on resveratrol are needed, especially those including maternal-fetal risk assessments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szukiewicz, Dariusz& Pyzlak, Michal& Szewczyk, Grzegorz& Stangret, Aleksandra& Trojanowski, Seweryn& Bachanek, Michal…[et al.]. 2017. High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1CX3CR1 Signaling in Human Placental Circulation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szukiewicz, Dariusz…[et al.]. High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1CX3CR1 Signaling in Human Placental Circulation. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szukiewicz, Dariusz& Pyzlak, Michal& Szewczyk, Grzegorz& Stangret, Aleksandra& Trojanowski, Seweryn& Bachanek, Michal…[et al.]. High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1CX3CR1 Signaling in Human Placental Circulation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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