Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review
المؤلفون المشاركون
Lorenzi, Maria
Amonkar, Mayur
Zhang, Jacky
Mehta, Shivani
Liaw, Kai-Li
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-09
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
Given limited data on the epidemiology of MSI-H and dMMR across solid tumors (except colorectal cancer (CRC)), the current study was designed to estimate their prevalence.
Materials and Methods.
A structured literature review identified English language publications that used immunohistochemistry (IHC) or polymerase chain replication (PCR) techniques.
Publications were selected for all tumors except CRC using MEDLINE, EMBASE, and Cochrane databases and key congresses; CRC and pan-tumor genomic publications were selected through a targeted review.
Meta-analysis was performed to estimate pooled prevalence of MSI-H/dMMR across all solid tumors and for selected tumor types.
Where possible, prevalence within tumor types was estimated by disease stages.
Results.
Of 1,176 citations retrieved, 103 and 48 publications reported prevalence of MSI-H and dMMR, respectively.
Five pan-tumor genomic studies supplemented the evidence base.
Tumor types with at least 5 publications included gastric (n = 39), ovarian (n = 23), colorectal (n = 20), endometrial (n = 53), esophageal (n = 6), and renal cancer (n = 8).
Overall MSI-H prevalence (with 95% CI) across 25 tumors was based on 90 papers (28,213 patients) and estimated at 14% (10%–19%).
MSI-H prevalence among Stage 1/2 cancers was estimated at 15% (8%–23%); Stages 3 and 4 prevalence was estimated at 9% (3%–17%) and 3% (1%–7%), respectively.
Overall, dMMR prevalence across 13 tumor types (based on 54 papers and 20,383 patients) was estimated at 16% (11%–22%).
Endometrial cancer had the highest pooled MSI-H and dMMR prevalence (26% and 25% all stages, respectively).
Conclusions.
This is the first comprehensive attempt to report pooled prevalence estimates of MSI-H/dMMR across solid tumors based on published data.
Prevalence determined by IHC and PCR was generally comparable, with some variations by cancer type.
Late-stage prevalence was lower than that in earlier stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lorenzi, Maria& Amonkar, Mayur& Zhang, Jacky& Mehta, Shivani& Liaw, Kai-Li. 2020. Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review. Journal of Oncology،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1188857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lorenzi, Maria…[et al.]. Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review. Journal of Oncology No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1188857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lorenzi, Maria& Amonkar, Mayur& Zhang, Jacky& Mehta, Shivani& Liaw, Kai-Li. Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1188857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر