Gelsolin Promotes Cancer Progression by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma and Correlates with a Poor Prognosis
المؤلفون المشاركون
Zhang, Yixi
Luo, Xiaojing
Lin, Jianwei
Fu, Shunjun
Feng, Pei
Su, Hongjun
He, Xiangjun
Liang, Xue
Liu, Kunpeng
Deng, Wen
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Gelsolin (GSN), a cytoskeletal protein, is frequently overexpressed in different cancers and promotes cell motility.
The biological function of GSN in hepatocellular carcinoma (HCC) and its mechanism remain unclear.
The expression of GSN was assessed in a cohort of 188 HCC patients.
The effects of GSN on the migration and invasion of tumour cells were examined.
Then, the role of GSN in tumour growth in vivo was determined by using a cancer metastasis assay.
The possible mechanism by which GSN promotes HCC progression was explored.
As a result, GSN was overexpressed in HCC tissues.
High GSN expression was significantly correlated with late Edmondson grade, encapsulation, and multiple tumours.
Patients with high GSN expression had worse overall survival (OS) and disease-free survival (DFS) than those with low GSN expression.
GSN expression was identified as an independent risk factor in both OS (hazard risk (HR) = 1.620, 95% confidence interval (CI) = 1.105–2.373, P<0.001) and DFS (HR = 1.744, 95% CI = 1.205–2.523, P=0.003).
Moreover, GSN knockdown significantly inhibited the migration and invasion of HCC tumour cells, while GSN overexpression attenuated these effects by regulating epithelial-mesenchymal transition (EMT) In conclusion, GSN promotes cancer progression and is associated with a poor prognosis in HCC patients.
GSN promotes HCC progression by regulating EMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yixi& Luo, Xiaojing& Lin, Jianwei& Fu, Shunjun& Feng, Pei& Su, Hongjun…[et al.]. 2020. Gelsolin Promotes Cancer Progression by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma and Correlates with a Poor Prognosis. Journal of Oncology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yixi…[et al.]. Gelsolin Promotes Cancer Progression by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma and Correlates with a Poor Prognosis. Journal of Oncology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1188860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yixi& Luo, Xiaojing& Lin, Jianwei& Fu, Shunjun& Feng, Pei& Su, Hongjun…[et al.]. Gelsolin Promotes Cancer Progression by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma and Correlates with a Poor Prognosis. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1188860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر