Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma
المؤلفون المشاركون
Li, Qi
Zhang, Qifan
Cheng, Xiao
Weng, Xie
Chen, Mian
Hu, Xiaoyun
Huang, Jing
Chen, Jinzhang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Tumor metastasis remains the leading cause of cancer-related mortality in biliary tract cancer.
The etiology and mechanism of bile tract carcinoma metastasis are unclear.
Methods.
The primary tumor and blood samples of 14 patients with biliary tract cancer were collected, followed by nucleic acid extraction and library construction.
Target sequencing with 556 panel genes and WES were performed to detect the hot spot genes variations.
Bioinformatics was used to comprehensively analyze the sequencing data of these samples, including the differences of tumor mutation burden and signaling pathways.
Results.
The results showed that the mutation frequency of TP53 gene was the highest and the mutations of CTNNB1, EPHA7, ARID2, and PIK3CA were only found in metastatic samples.
The TMB mean values of metastatic and non-metastatic groups were 12.97 and 10.38 mutations per Mb, respectively.
There were significant differences in the enrichment pathways of cellular components between the tumor metastasis and non-metastatic samples.
Conclusions.
We identified multiple pathway differences, which helps us better understand metastatic biliary tumors and design clinical therapy for personalized medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Qi& Zhang, Qifan& Cheng, Xiao& Weng, Xie& Chen, Mian& Hu, Xiaoyun…[et al.]. 2020. Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Qi…[et al.]. Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1188896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Qi& Zhang, Qifan& Cheng, Xiao& Weng, Xie& Chen, Mian& Hu, Xiaoyun…[et al.]. Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر