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Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase BAkt Signaling
المؤلفون المشاركون
Yu, Minghui
Gao, Qiang
Yu, Guihong
Wang, Xinping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Aim.
We aimed to explore the effects of Bupleuri Radix (BR) on the recurrence of resected colonic polyp (CP) by measuring angiogenin-2-induced protein kinase B (Ang PKB)/Akt signaling.
Method.
The main ingredients of BR were extracted by using ethanol and measured by HPLC.
One hundred twenty patients with CP >10 mm who underwent resected surgery were randomly allocated to an aspirin (AG) or a BR medicine (BG) group.
The allocation ratio was 1 : 1 and the intervention duration was one year.
The recurrence rate of resected CP was investigated and the plasma levels of Ang PKB/Akt and inflammatory cytokines were measured using ELISA kits.
After one-year surgery, side effects were recorded.
The relationship between the serum levels of the main compounds of BR and plasma levels of Ang PKB/Akt was analyzed.
Results.
The main ingredients of CP are paeoniflorin, baicalin, saikosaponin A, and bupleurum saponin B2.
Recurrence of resected CP was found in 17 patients from the AG group and eight patients from the BG group after one-year follow-up p<0.05.
The levels of angiogenin-2 II and PKB/Akt in the AG group were higher than those in the BG group p<0.05.
Meanwhile, BR treatment reduced the plasma levels of TNF-α, IL-1β, and IL-6, and increased the level of IL-10p<0.05.
Inflammatory cytokines are important factors that affect the recurrence of resected CP.
Serum paeoniflorin, baicalin, saikosaponin A, and bupleurum saponin B2 in BR had a strong negative relationship with the plasma levels of Ang PKB/Akt.
Conclusion.
BR significantly reduces the recurrence risk of resected CP by affecting Ang PKB/Akt signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Qiang& Yu, Guihong& Yu, Minghui& Wang, Xinping. 2020. Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase BAkt Signaling. Journal of Oncology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188902
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Qiang…[et al.]. Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase BAkt Signaling. Journal of Oncology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1188902
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Qiang& Yu, Guihong& Yu, Minghui& Wang, Xinping. Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase BAkt Signaling. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1188902
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188902
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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