Clinical and Survival Impact of Sex-Determining Region Y-Box 2 in Colorectal Cancer: An Integrated Analysis of the Immunohistochemical Study and Bioinformatics Analysis
المؤلفون المشاركون
Song, Kun
Hao, Jingduo
Ge, Zuyin
Chen, Pushi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Transcription factor sex-determining region Y-box 2 (SOX2) involves in the maintenance of cancer stem cells.
However, the role of SOX2 in colorectal cancer (CRC) remains unclear.
This study was conducted to investigate the effect of SOX2 on CRC.
Studies were searched using electronic databases.
The combined odds ratios (ORs) or hazard ratios (HRs: multivariate Cox survival analysis) with their 95% confidence intervals (CIs) were calculated.
The Cancer Genome Atlas (TCGA) and GEO datasets were further applied to validate the survival effect.
The functional analysis of SOX2 was investigated.
In this work, 13 studies including 2337 patients were identified, and validation data were enrolled from TCGA and GEO datasets.
SOX2 expression was not significantly related to age, gender, microsatellite instability (MSI) status, clinical stage, histological grade, tumor size, pT-stage, lymph node metastasis, distal metastasis, and cancer-specific survival (CSS) but was correlated with worse overall survival (OS: n = 536 patients) (P<0.05).
Furthermore, TCGA data demonstrated similar results, with no significant correlation between SOX2 and pathological characteristics.
Further validation data (OS: n = 1408 and disease-free survival (DFS): n = 1367) showed that SOX2 expression was correlated with worse OS (HR = 1.35, 95% CI: 1.11–1.65, P=0.004) and DFS (HR = 1.30, 95% CI: 1.04–1.62, P=0.02).
The functional analyses showed that SOX2 involved in cell-cell junction, focal adhesion, extracellular matrix- (ECM-) receptor interaction, and MAP kinase activity.
Our findings suggest that SOX2 expression may be correlated with the worse prognosis of CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Kun& Hao, Jingduo& Ge, Zuyin& Chen, Pushi. 2020. Clinical and Survival Impact of Sex-Determining Region Y-Box 2 in Colorectal Cancer: An Integrated Analysis of the Immunohistochemical Study and Bioinformatics Analysis. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Kun…[et al.]. Clinical and Survival Impact of Sex-Determining Region Y-Box 2 in Colorectal Cancer: An Integrated Analysis of the Immunohistochemical Study and Bioinformatics Analysis. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Kun& Hao, Jingduo& Ge, Zuyin& Chen, Pushi. Clinical and Survival Impact of Sex-Determining Region Y-Box 2 in Colorectal Cancer: An Integrated Analysis of the Immunohistochemical Study and Bioinformatics Analysis. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر