Immunotherapy: Newer Therapeutic Armamentarium against Cancer Stem Cells
المؤلفون المشاركون
Singh, Saurabh Pratap
Gupta, Shalini
Singh, Richa
Gupta, Om Prakash
Brahma Bhatt, Madan Lal
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Mounting evidence from the literature suggests the existence of a subpopulation of cancer stem cells (CSCs) in almost all types of human cancers.
These CSCs possessing a self-renewal capacity inhabit primary tumors and are more defiant to standard antimitotic and molecularly targeted therapies which are used for eliminating actively proliferating and differentiated cancer cells.
Clinical relevance of CSCs emerges from the fact that they are the root cause of therapy resistance, relapse, and metastasis.
Earlier, surgery, chemotherapy, and radiotherapy were established as cancer treatment modalities, but recently, immunotherapy is also gaining importance in the management of various cancer patients, mostly those of the advanced stage.
This review abridges potential off-target effects of inhibiting CSC self-renewal pathways on immune cells and some recent immunological studies specifically targeting CSCs on the basis of their antigen expression profile, even though molecular markers or antigens that have been described till date as expressed by cancer stem cells are not specifically expressed by these cells which is a major limitation to target CSCs.
We propose that owing to CSC stemness property to mediate immunotherapy response, we can apply a combination therapy approach by targeting CSCs and tumor microenvironment (TME) along with conventional treatment strategies as an effective means to eradicate cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Saurabh Pratap& Singh, Richa& Gupta, Om Prakash& Gupta, Shalini& Brahma Bhatt, Madan Lal. 2020. Immunotherapy: Newer Therapeutic Armamentarium against Cancer Stem Cells. Journal of Oncology،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Saurabh Pratap…[et al.]. Immunotherapy: Newer Therapeutic Armamentarium against Cancer Stem Cells. Journal of Oncology No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1188927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Saurabh Pratap& Singh, Richa& Gupta, Om Prakash& Gupta, Shalini& Brahma Bhatt, Madan Lal. Immunotherapy: Newer Therapeutic Armamentarium against Cancer Stem Cells. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188927
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر