Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis
المؤلفون المشاركون
Goulart, Luiz Ricardo
Sabino-Silva, Robinson
Ferreira, Izabella C. C.
Aguiar, Emília M. G.
Silva, Alinne T. F.
Santos, Letícia L. D.
Cardoso-Sousa, Léia
Araújo, Thaise G.
Santos, Donizeti W.
Maia, Yara C. P.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Saliva biomarkers using reagent-free biophotonic technology have not been investigated as a strategy for early detection of breast cancer (BC).
The attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy has been proposed as a promising tool for disease diagnosis.
However, its utilization in cancer is still incipient, and currently saliva has not been used for BC screening.
We have applied ATR-FTIR onto saliva from patients with breast cancer, benign breast disease, and healthy matched controls to investigate its potential use in BC diagnosis.
Several salivary vibrational modes have been identified in original and second-derivative spectra.
The absorbance levels at wavenumber 1041 cm−1 were significantly higher (p<0.05) in saliva of breast cancer patients compared with those of benign patients, and the ROC curve analysis of this peak showed a reasonable accuracy to discriminate breast cancer from benign and control patients.
The 1433–1302.9 cm−1 band area was significantly higher (p<0.05) in saliva of breast cancer patients than in control and benign patients.
This salivary ATR-FTIR spectral area was prevalidated as a potential diagnostic biomarker of BC.
This spectral biomarker was able to discriminate human BC from controls with sensitivity and specificity of 90% and 80%, respectively.
Besides, it was able to differentiate BC from benign disease with sensitivity and specificity of 90% and 70%, respectively.
Briefly, for the first time, saliva analysis by ATR-FTIR spectroscopy has demonstrated the potential use of salivary spectral biomarkers (1041 cm−1 and 1433–1302.9 cm−1) as a novel alternative for noninvasive BC diagnosis, which could be used for screening purposes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferreira, Izabella C. C.& Aguiar, Emília M. G.& Silva, Alinne T. F.& Santos, Letícia L. D.& Cardoso-Sousa, Léia& Araújo, Thaise G.…[et al.]. 2020. Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferreira, Izabella C. C.…[et al.]. Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1188951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferreira, Izabella C. C.& Aguiar, Emília M. G.& Silva, Alinne T. F.& Santos, Letícia L. D.& Cardoso-Sousa, Léia& Araújo, Thaise G.…[et al.]. Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1188951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر