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An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
المؤلفون المشاركون
Wei, Jingsun
Ge, Xiaoxu
Tang, Yang
Qian, Yucheng
Lu, Wei
Jiang, Kai
Fang, Yimin
Hwang, Maxwell
Fu, Dongliang
Xiao, Qian
Ding, Kefeng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Purpose.
Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis.
As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer.
Methods.
In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes.
Subsequently, univariate Cox regression analysis was used to investigate 32 autophagy-related lncRNAs linked to colon cancer prognosis.
Subsequently, eight of the 32 autophagy-related lncRNAs (i.e., long intergenic nonprotein coding RNA 1503 [LINC01503], ZEB1 antisense RNA 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, and TNFRSF10A-AS1) were selected through multivariate Cox regression analysis.
Based on these autophagy-related lncRNAs, a risk signature was constructed, and the patients were divided into high- and low-risk groups.
Results.
The high-risk group’s overall survival time was significantly shorter than that of the low-risk group p<0.0001.
Receiver operating characteristic curve analysis was performed to further confirm the validity of the model (area under the curve: 0.689).
Moreover, multivariate regression suggested that the risk score was a significant prognostic risk factor in colorectal cancer.
Gene set enrichment analysis showed that these gene sets are significantly enriched in cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling.
Conclusion.
The risk signature of eight autophagy-related lncRNAs has prognostic potential for colorectal cancer.
These autophagy-related lncRNAs may play a vital role in the biology of colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Jingsun& Ge, Xiaoxu& Tang, Yang& Qian, Yucheng& Lu, Wei& Jiang, Kai…[et al.]. 2020. An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1188963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Jingsun…[et al.]. An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer. Journal of Oncology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1188963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Jingsun& Ge, Xiaoxu& Tang, Yang& Qian, Yucheng& Lu, Wei& Jiang, Kai…[et al.]. An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1188963
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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