Identification of a Prognostic Risk Signature of Kidney Renal Clear Cell Carcinoma Based on Regulating the Immune Response Pathway Exploration
المؤلفون المشاركون
Li, Jiayi
Wu, Guangzhen
Xu, Yingkun
Han, Chenglin
Wang, Zilong
Wang, Qifei
Che, Xiangyu
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To construct a survival model for predicting the prognosis of patients with kidney renal clear cell carcinoma (KIRC) based on gene expression related to immune response regulation.
Materials and Methods.
KIRC mRNA sequencing data and patient clinical data were downloaded from the TCGA database.
The pathways and genes involved in the regulation of the immune response were identified from the GSEA database.
A single factor Cox analysis was used to determine the association of mRNA in relation to patient prognosis P<0.05.
The prognostic risk model was further established using the LASSO regression curve.
The survival prognosis model was constructed, and the sensitivity and specificity of the model were evaluated using the ROC curve.
Results.
Compared with normal kidney tissues, there were 28 dysregulated mRNA expressions in KIRC tissues P<0.05.
Univariate Cox regression analysis revealed that 12 mRNAs were related to the prognosis of patients with renal cell carcinoma.
The LASSO regression curve drew a risk signature consisting of six genes: TRAF6, FYN, IKBKG, LAT2, C2, IL4, EREG, TRAF2, and IL12A.
The five-year ROC area analysis (AUC) showed that the model has good sensitivity and specificity (AUC >0.712).
Conclusion.
We constructed a risk prediction model based on the regulated immune response-related genes, which can effectively predict the survival of patients with KIRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Guangzhen& Xu, Yingkun& Han, Chenglin& Wang, Zilong& Li, Jiayi& Wang, Qifei…[et al.]. 2020. Identification of a Prognostic Risk Signature of Kidney Renal Clear Cell Carcinoma Based on Regulating the Immune Response Pathway Exploration. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189043
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Guangzhen…[et al.]. Identification of a Prognostic Risk Signature of Kidney Renal Clear Cell Carcinoma Based on Regulating the Immune Response Pathway Exploration. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189043
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Guangzhen& Xu, Yingkun& Han, Chenglin& Wang, Zilong& Li, Jiayi& Wang, Qifei…[et al.]. Identification of a Prognostic Risk Signature of Kidney Renal Clear Cell Carcinoma Based on Regulating the Immune Response Pathway Exploration. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189043
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189043
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر