A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche

المؤلفون المشاركون

Vacca, Angelo
Solimando, Antonio Giovanni
Ribatti, Domenico

المصدر

Journal of Oncology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-18

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

There is a broad spectrum of diseases labeled as multiple myeloma (MM).

This is due not only to the composite prognostic risk factors leading to different clinical outcomes and responses to treatments but also to the composite tumor microenvironment that is involved in a vicious cycle with the MM plasma cells.

New therapeutic strategies have improved MM patients’ chances of survival.

Nevertheless, certain patients’ subgroups have a particularly unfavorable prognosis.

Biological stratification can be subdivided into patient, disease, or therapy-related factors.

Alternatively, the biological signature of aggressive disease and dismal therapeutic response can promote a dynamic, comprehensive strategic approach, better tailoring the clinical management of high-risk profiles and refractoriness to therapy and taking into account the role played by the MM milieu.

By means of an extensive literature search, we have reviewed the state-of-the-art pathophysiological insights obtained from translational investigations of the MM-bone marrow microenvironment.

A good knowledge of the MM niche pathophysiological dissection is crucial to tailor personalized approaches in a bench-bedside fashion.

The discussion in this review pinpoints two main aspects that appear fundamental in order to gain novel and definitive results from the biology of MM.

A systematic knowledge of the plasma cell disorder, along with greater efforts to face the unmet needs present in MM evolution, promises to open a new therapeutic window looking out onto the plethora of scientific evidence about the myeloma and the bystander cells.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Solimando, Antonio Giovanni& Vacca, Angelo& Ribatti, Domenico. 2020. A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche. Journal of Oncology،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1189056

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Solimando, Antonio Giovanni…[et al.]. A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche. Journal of Oncology No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1189056

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Solimando, Antonio Giovanni& Vacca, Angelo& Ribatti, Domenico. A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1189056

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1189056