Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIBC Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study
المؤلفون المشاركون
Ozdemir, Yurday
Mertsoylu, Huseyin
Kucuk, Ahmet
Besen, Ali Ayberk
Sezer, Ahmet
Sezen, Duygu
Bolukbasi, Yasemin
Pehlivan, Berrin
Topkan, Erkan
Selek, Ugur
Guler, Ozan Cem
Akdemir, Eyub Yasar
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
We retrospectively compared the incidence of isolated elective nodal failure (IENF) and toxicity rates and survival outcomes after elective nodal irradiation (ENI) versus involved-field RT (IFRT) by employing the propensity score matching (PSM) methodology in stage IIIB/C inoperable non-small-cell lung cancer (NSCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT).
Methods.
Our PSM examination included 1048 stage IIIB/C NSCLC patients treated with C-CRT from January 2007 to December 2016: a total dose of 66 Gy (2 Gy/fraction) radiotherapy and 1–3 cycles of platinum-based doublet chemotherapy concurrently.
The primary and secondary endpoints were the IENF and toxicity rates and survival outcomes after ENI versus IFRT, respectively.
Propensity scores were calculated for each group to adjust for confounding variables and facilitate well-balanced comparability by creating 1 : 1 matched study groups.
Results.
The median follow-up was 26.4 months for the whole study accomplice.
The PSM analysis unveiled 1 : 1 matched 646 patients for the ENI (N = 323) and IFRT (N = 323) cohorts.
Intergroup comparisons discovered that the 5-year isolated ENF incidence rates (3.4% versus 4.3%; P=0.52) and median overall survival (25.2 versus 24.6 months; P=0.69), locoregional progression-free survival (15.3 versus 15.1 months; P=0.52), and progression-free survival (11.7 versus 11.2 months; P=0.57) durations were similar between the ENI and IFRT cohorts, separately.
However, acute grade 3-4 leukopenia (P=0.0012), grade 3 nausea-vomiting (P=0.006), esophagitis (P=0.003), pneumonitis (P=0.002), late grade 3-4 esophageal toxicity (P=0.038), and the need for hospitalization (P<0.001) were all significantly higher in the ENI than in the IFRT group, respectively.
Conclusion.
Results of the present large-scale PSM cohort established the absence of meaningful IENF or survival differences between the IFRT and ENI cohorts and, consequently, counseled the IFRT as the elected RT technique for such patients since ENI increased the toxicity rates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Topkan, Erkan& Ozdemir, Yurday& Guler, Ozan Cem& Kucuk, Ahmet& Besen, Ali Ayberk& Mertsoylu, Huseyin…[et al.]. 2020. Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIBC Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Topkan, Erkan…[et al.]. Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIBC Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Topkan, Erkan& Ozdemir, Yurday& Guler, Ozan Cem& Kucuk, Ahmet& Besen, Ali Ayberk& Mertsoylu, Huseyin…[et al.]. Comparison of Involved Field Radiotherapy versus Elective Nodal Irradiation in Stage IIIBC Non-Small-Cell Lung Carcinoma Patients Treated with Concurrent Chemoradiotherapy: A Propensity Score Matching Study. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر