Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer

المؤلفون المشاركون

Gu, Jincheng
Cao, Jianping
Qin, Hualong
Tang, Zaixiang
Xin, Dongrun
Liu, Jingfang
Ji, Yujie
Jin, Jiawei
Sun, Lu
Tai, Qingliang
Tian, Ye

المصدر

Journal of Oncology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-07-20

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

DEXD/H box helicase 60 (DDX60) is a new type of DEAD-box RNA helicase, which is induced to express after virus infection.

It might involve in antiviral immunity by promoting RIG-I-like receptor-mediated signal transduction.

In addition, previous studies had shown that the expression of DDX60 is related to cancer, but there was still a lack of relevant research in breast cancer.

In this study, we used the information of patients with breast cancer in the TCGA database for statistical analysis and found that the breast cancer patients with low expression of DDX60 exhibited radiosensitivity.

Comparing the radiotherapy groups with the nonradiotherapy groups, for patients with low expression of DDX60, the adjusted hazard ratio (HR) values for radiotherapy were 0.244 (0.064–0.921) and 0.199 (0.062–0.646) in the training and validation datasets, with the p values 0.040 and 0.007, respectively.

However, for patients with high expression of DDX60, the adjusted hazard ratio (HR) values were 3.582 (0.627–20.467) and 2.421 (0.460–12.773), with the p values 0.054 and 0.297, respectively.

These results suggested that the expression of DDX60 might strongly associate with individualized radiosensitivity in patients with breast cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xin, Dongrun& Liu, Jingfang& Gu, Jincheng& Ji, Yujie& Jin, Jiawei& Sun, Lu…[et al.]. 2020. Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189108

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xin, Dongrun…[et al.]. Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189108

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xin, Dongrun& Liu, Jingfang& Gu, Jincheng& Ji, Yujie& Jin, Jiawei& Sun, Lu…[et al.]. Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189108

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1189108