Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203HK2 Axis in Esophagal Cancer
المؤلفون المشاركون
Liu, Hai-E
Shi, Hao-Hong
Luo, Xing-Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Reprogrammed glucose metabolism of enhanced aerobic glycolysis, also known as Warburg effect, which exerts a significant contributor to cancer progression, is regarded as a hallmark of cancer.
The roles of long noncoding RNAs (lncRNA) in regulating cancer via metabolic reprogramming are mostly unknown, including esophagal cancer (EC).
Here, we showed that how the lncRNA urothelial carcinoma associated 1 (UCA1) exerts pro-oncogene in regulating EC glucose metabolism.
Firstly, we found that upregulated UCA1 expression enhances the malignant phenotypes of EC, including poor outcome, larger tumor size, positive lymphatic invasion, and advanced pathological stages.
UCA1 silencing could suppress EC cell proliferation and metastasis.
Following, bioinformatics analyses revealed that UCA1 regulated the HK2 expression through functioning as a competing endogenous RNA (ceRNA).
Mechanistically, UCA1 overexpression could elevate the activation of HK2 oncogenes via inhibition of miR-203 activity, as evidenced by the positive correlation of UCA1 with HK2 and inverse correlation with miR-203 expression.
Luciferase activity assay further verified the targeting relationship between UCA1, miR-203, and HK2.
Upregulated UCA1 in EC cells significantly suppressed the degradation of HK2 by miR-203.
Further research showed that upregulated UCA1 effectively increased the rate of glucose uptake, lactate output, and ECAR value, all of which can be attenuate by HK2 interference and 2-DG, whereas knockdown of UCA1 had the opposite effect.
In sum, our findings suggest that the UCA1/miR-203/HK2 axis contributes to EC development by reprogramming tumor glucose metabolism, providing new insight into the management of EC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hai-E& Shi, Hao-Hong& Luo, Xing-Jing. 2020. Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203HK2 Axis in Esophagal Cancer. Journal of Oncology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hai-E…[et al.]. Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203HK2 Axis in Esophagal Cancer. Journal of Oncology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hai-E& Shi, Hao-Hong& Luo, Xing-Jing. Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203HK2 Axis in Esophagal Cancer. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر