Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?
المؤلفون المشاركون
El-Saka, Ayman M.
Zamzam, Yomna A.
Zamzam, Yosra A.
El-Dorf, Ayman
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background & Aims.
Endometrial tubal metaplasia (ETM) is mostly described in conjunction with unopposed estrogen levels, and its association with endometrial hyperplasia and endometrial carcinoma (EC) is striking.
Obesity is a risk factor for endometrial hyperplasia and EC development.
The aim of this study is to investigate the impact of BMI and serum estradiol level on expression of PAX-2, H-TERT, P16, Ki-67, and P53 in studied ETM in reference to benign endometrium and EC.
Methods.
The study was conducted on the following groups: group (1) consists of 57 cases that had endometrial biopsies with histologically demonstrable ETM (typical or atypical) and all were subjected to serum estradiol levelling and body mass index (BMI) evaluation; group (2) had adjacent benign endometrial tissue as control; group (3) consists of 52 cases of conventional endometrial carcinoma and 16 serous carcinoma paraffin blocks which were collected and reevaluated.
All included groups were immunostained for PAX-2, H-TERT, p16, ki67, and p53.
Results.
The relation between BMI and serum estradiol level in group 1 and PAX-2, H-TERT, P16, and p53 was statistically significant, while their relation with atypia and ki67 expression was insignificant.
Twenty-three ETM cases (40.4%) out of group 1 were all (100%) obese, 87% had high serum estradiol level, and 73.9% were postmenopausal and had a similar immunohistochemical profile as EC cases (group 3).
Conclusions.
The presence of ETM regardless of the histologic atypia in obese postmenopausal patients with high serum estradiol level is an alarming sign.
This implies that ETM might not be as benign as generally accepted, as under certain clinical conditions, it may turn into a potential premalignant lesion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Saka, Ayman M.& Zamzam, Yomna A.& Zamzam, Yosra A.& El-Dorf, Ayman. 2020. Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?. Journal of Obesity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1189226
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Saka, Ayman M.…[et al.]. Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?. Journal of Obesity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1189226
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Saka, Ayman M.& Zamzam, Yomna A.& Zamzam, Yosra A.& El-Dorf, Ayman. Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?. Journal of Obesity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1189226
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189226
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر