Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes
المؤلفون المشاركون
Wang, Zhaoyang
Yao, Teng-teng
Jin, Xiao-liang
Yang, Yuan
Wang, Yi-xiao
Zhou, Ya-li
He, Fang-lin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the ocular pharmacokinetic properties of subretinal conbercept injection in vitrectomized rabbit eyes and to compare them with those by intravitreal injection.
Methods.
The following groups of New Zealand white rabbits received conbercept injections (0.5 mg/0.05 ml): a subretinal group (subretinal injection in vitrectomized eyes), an intravitreal group (intravitreal injection in vitrectomized eyes), and a control group (intravitreal injection in nonvitrectomized eyes).
Drug concentrations in the aqueous humor (AH), the vitreous humor (VH), and the retina were measured by the enzyme-linked immunosorbent assay (ELISA), and pharmacokinetic parameters were calculated.
Ophthalmic B-ultrasonography, electroretinogram (ERG), and hematoxylin and eosin (H&E) staining were performed to evaluate the safety of subretinal injection.
Results.
On the 28th day after injection, the drug level in the subretinal group was significantly higher than that in the intravitreal group in the AH (0.90 ± 0.25 μg/ml and 0.11 ± 0.07 μg/ml, P<0.001, respectively) and the VH (5.00 ± 3.86 μg/ml and 0.40 ± 0.34 μg/ml, P=0.016, respectively).
The clearance rate from AH and VH exhibited terminal half-life times of 9.88 ± 6.48 days and 6.14 ± 1.69 days by the subretinal application, which were significantly longer than the half-life in AH (3.34 ± 0.58 days, P=0.004) and VH (3.12 ± 0.45 days, P=0.002) by the intravitreal application to the vitrectomized eyes.
No significant physiological and anatomical functional changes in the retina were observed after subretinal conbercept injection.
Conclusions.
Our study indicates that applying conbercept by subretinal injection can reduce the drug clearance rate and sustain a long maintenance period in ocular tissue, which suggests that subretinal conbercept injection may be a potentially valuable treatment option.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Teng-teng& Jin, Xiao-liang& Yang, Yuan& Wang, Yi-xiao& Zhou, Ya-li& He, Fang-lin…[et al.]. 2020. Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189337
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Teng-teng…[et al.]. Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes. Journal of Ophthalmology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1189337
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Teng-teng& Jin, Xiao-liang& Yang, Yuan& Wang, Yi-xiao& Zhou, Ya-li& He, Fang-lin…[et al.]. Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1189337
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189337
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر