Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration
المؤلفون المشاركون
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Age-related macular degeneration (AMD) is the leading cause of severe, permanent vision loss among the elderly in the developed world.
The cellular and molecular pathogenesis of initiation and development of AMD remain poorly delineated.
The limited resources of the human AMD RPE/choroid tissues impeded the extensive study of the disease.
To better understand the molecular and pathway changes in human AMD RPE/choroid tissues, we searched the literature and found three independent studies using high-throughput technology to analyze gene expression in 54 human AMD RPE/choroid tissues and 46 age-matched healthy controls.
We downloaded these data, pooled them together, and reanalyzed the difference between molecular and pathways by the Ingenuity Pathway Analysis (IPA) database.
Totally, 353 differentially expressed genes (DEGs) were identified, among which 181 genes were downregulated and 172 genes were upregulated in RPE/choroid of AMD patients.
Furthermore, several significantly enriched biological processes, including cancer, organismal injury and abnormalities, and ophthalmic disease, were identified associated with these DEGs.
By analysis of canonical pathway, the phototransduction pathway and atherosclerosis signaling were the top two significant canonical pathways altered in RPE/choroid tissues in human AMD.
As expected, several ophthalmic disease-related molecules, including RHO, PDE6A, 3′,5′-cyclic-GMP phosphodiesterase, and G protein alpha, were in the central nodes of disease network.
The bioinformatics technology combined with the existing high-throughput data was applied to evaluate the underlying key genes and pathways in human AMD tissues, which may predict downstream and upstream biological processes and identify potential therapeutic intervention targets in human AMD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Junyu& Zhou, Yu. 2020. Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189338
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Junyu& Zhou, Yu. Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration. Journal of Ophthalmology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1189338
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Junyu& Zhou, Yu. Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189338
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189338
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر