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Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand
المؤلفون المشاركون
Rojanaporn, Duangnate
Attaseth, Taweevat
Dieosuthichat, Wimwipa
Leelawongs, Kitikul
Pakakasama, Samart
Anurathapan, Usanarat
Chanthanaphak, Ekachat
Singhara Na Ayudhaya, Sirintara
Hongeng, Suradej
Aroonroch, Rangsima
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the clinical presentations and outcomes of retinoblastoma in relation to the advent of new multimodal treatments in Thailand.
Patients and Methods.
Retrospective case series.
We evaluated the clinical presentation, staging, details of treatment, and treatment outcomes of retinoblastoma patients who were treated at Ramathibodi Hospital, Bangkok, Thailand, between January 1, 2007, and December 31, 2018.
The log-rank test was used to explore clinical characteristics and treatment modalities that affected globe salvage and survival curves.
Results.
This study included 124 eyes of 81 patients with retinoblastoma.
Forty-three patients (53.1%) had bilateral retinoblastoma.
The median age at diagnosis was 8 months (range, 1–48 months).
Of 124 eyes, 9 eyes (7.3%) had extraocular retinoblastoma and 115 eyes (92.7%) had intraocular retinoblastoma, which were classified by the International Classification of Retinoblastoma (ICRB) as group A, 4 eyes (3.5%); group B, 19 eyes (16.5%); group C, 6 eyes (5.2%); group D, 31 eyes (27%); and group E, 56 eyes (47.8%).
Treatment included systemic chemotherapy, intra-arterial chemotherapy, ruthenium-106 plaque brachytherapy, external beam radiation therapy, cryotherapy, transpupillary thermotherapy, subtenon chemotherapy, and intravitreal chemotherapy.
At the median follow-up period of 38.4 months (range, 0.2–148.2 months), the overall globe salvage rate of intraocular retinoblastoma was 51.7%.
For unilateral retinoblastoma, globe salvage rate was 37.5% (group B, 100%; group C, 100%; group D, 50%; and group E, 18.8%).
For bilateral intraocular retinoblastoma, the globe salvage rate was 57.8% (group A, 100 %; group B, 94.4%; group C, 100%; group D, 64.7%; and group E, 28.2%).
The overall survival rate was 93.8%.
Conclusions.
Recent advanced treatment modalities have improved the probability of globe salvage.
However, enucleation remains an important life-saving intervention in many advanced cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rojanaporn, Duangnate& Attaseth, Taweevat& Dieosuthichat, Wimwipa& Leelawongs, Kitikul& Pakakasama, Samart& Anurathapan, Usanarat…[et al.]. 2020. Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rojanaporn, Duangnate…[et al.]. Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand. Journal of Ophthalmology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1189388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rojanaporn, Duangnate& Attaseth, Taweevat& Dieosuthichat, Wimwipa& Leelawongs, Kitikul& Pakakasama, Samart& Anurathapan, Usanarat…[et al.]. Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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