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Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany
المؤلفون المشاركون
Ziemssen, Focke
Wachtlin, Joachim
Spital, Georg
Schmitz-Valckenberg, Steffen
Vögeler, Jessica
Müller, Bettina
Ocean study group, Focke
Liakopoulos, Sandra
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
To date, there are limited prospective real-world data on the impact of optical coherence tomography (OCT) diagnostics on treatment outcomes in neovascular age-related macular degeneration (nAMD).
Therefore, the prospective, noninterventional OCEAN study (NCT02194803) evaluated the use of OCT imaging and its impact on functional outcomes in Germany.
Methods.
The use of OCT imaging for treatment decisions was documented in nAMD patients receiving intravitreal ranibizumab injections at 347 study centres.
Best-corrected visual acuity (BCVA) testing and treatment were performed according to routine clinical practice and documented over 24 months.
Results.
The majority of the 3,631 nAMD patients (59.6%) received a combination of OCT and fluorescein angiography imaging within the first 6 months.
Over the remaining study course, this combination was used infrequently (range: 7.6% to 13.4%) and continually decreased over time; most patients received only OCT examinations (range: 48.9% to 52.5%; median: 3 within 12 months and 4 within 24 months).
Subgroups according to the number of OCT examinations (≤4, rarely OCT examined; 5–8, moderately OCT examined; ≥8, well monitored) were associated with different treatment frequencies and outcomes: Rarely OCT-examined patients had received a median of 4 injections (range: 1–19) at 24 months; well-monitored patients had received a median of 8 injections (range: 1–21) at 24 months.
Rarely OCT-examined patients had a mean change of BCVA of −0.3 letters (±26.1) at 24 months (n = 165); well-monitored patients showed a change of +2.0 letters (±20.8) at 24 months (n = 249).
Time-to-response was greater for rarely examined than well-monitored patients, while duration-of-response was similar.
Conclusion.
Low number of visits as well as high number of treatment decisions without the use of OCT may contribute to undertreatment and poorer functional outcomes in patients undergoing ranibizumab treatment for nAMD in Germany.
One potential reason for this could be that OCT was not covered by insurance for all patients during the study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wachtlin, Joachim& Spital, Georg& Schmitz-Valckenberg, Steffen& Liakopoulos, Sandra& Vögeler, Jessica& Müller, Bettina…[et al.]. 2020. Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wachtlin, Joachim…[et al.]. Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany. Journal of Ophthalmology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1189708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wachtlin, Joachim& Spital, Georg& Schmitz-Valckenberg, Steffen& Liakopoulos, Sandra& Vögeler, Jessica& Müller, Bettina…[et al.]. Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1189708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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