Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity
المؤلفون المشاركون
Ozcan, Yasin
Huseyin, Gumus
Sonmez, Kenan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
The aim of this study is to ascertain whether the level of circulating amino acids (aa) is associated with retinopathy of prematurity (ROP).
Methods.
This is a randomized controlled study of 55 infants born at gestational age (GA) ≤32 weeks or birth weight (BW) ≤1500 grams.
Serum samples were obtained from two groups: Group A comprised of 26 preterm infants with ROP and Group B comprised of 29 preterm infants without ROP.
Plasma aa levels were analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS).
Correlation test and multivariate regression analysis were used to evaluate the relationship between plasma aa levels and variables.
Results.
The mean serum arginine and glutamine levels were significantly higher, but the mean lysine and aspartic acid levels were significantly lower in Group A, compared to Group B (p=0.04, p=0.002, p=0.029, and p=0.002, respectively).
In multivariate analysis, the mean arginine and lysine levels were significantly associated with the stage of the disease (p=0.03 and p=0.01, respectively).
No significant differences were determined between the groups in terms of alanine, asparagine, valine, leucine, phenylalanine, tyrosine, serine, proline, citrulline, cysteine, ornithine, tryptophan, methionine, threonine, taurine, and isoleucine amino acids (p>0.05, respectively).
Conclusions.
These results indicate a significant association between high arginine and glutamine, with low lysine and aspartic acid serum concentrations with ROP.
Due to higher serum concentrations in ROP, extra arginine-glutamine supplementation in hyperoxic conditions may be unfavorable through pathways involving reactive oxygen, particularly in patients with ROP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ozcan, Yasin& Huseyin, Gumus& Sonmez, Kenan. 2020. Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ozcan, Yasin…[et al.]. Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity. Journal of Ophthalmology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1189710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ozcan, Yasin& Huseyin, Gumus& Sonmez, Kenan. Evaluation of Plasma Amino Acid Levels in Preterm Infants and Their Potential Correlation with Retinopathy of Prematurity. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر