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Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma
المؤلفون المشاركون
Ishida, Susumu
Kikuchi, Kasumi
Murata, Miyuki
Dong, Zhenyu
Shinmei, Yasuhiro
Kanda, Atsuhiro
Noda, Kosuke
Harada, Takayuki
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies.
Lowering intraocular pressure is currently the only way to treat glaucoma, but it is often insufficient to inhibit the progression of the disease.
Glaucoma is a multifactorial disease, and the involvement of oxidative stress has recently received much attention.
In the present study, we investigated the cytoprotective effect of astaxanthin (AST) on RGC degeneration using a normal-tension glaucoma (NTG) mouse model, which lacks the glutamate/aspartate transporter (Glast) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure.
Three-week-old Glast± mice were given intraperitoneal injections of AST at 10, 30, or 60 mg/kg/day or vehicle alone, and littermate control mice were given vehicle alone for 14 days, respectively.
Five weeks after birth, the number of RGCs was counted in paraffin sections of retinal tissues stained with hematoxylin and eosin.
We also used a retrograde labeling technique to quantify the number of RGCs.
Additionally, the phosphorylated (p) IκB/total IκB ratio and the 4-hydroxynonenal (HNE) were measured in retinal tissues.
The number of RGCs in Glast± mice was significantly decreased compared with that in control mice.
RGC loss was suppressed by the administration of AST at 60 mg/kg/day, compared with vehicle alone.
Following AST administration, the concentration of 4-HNE in the retina was also suppressed, but the pIκB/IκB ratio did not change.
Our study revealed that the antioxidative stress effects of AST inhibit RGC degeneration in the retina and may be useful in the treatment of NTG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kikuchi, Kasumi& Dong, Zhenyu& Shinmei, Yasuhiro& Murata, Miyuki& Kanda, Atsuhiro& Noda, Kosuke…[et al.]. 2020. Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kikuchi, Kasumi…[et al.]. Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma. Journal of Ophthalmology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1189906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kikuchi, Kasumi& Dong, Zhenyu& Shinmei, Yasuhiro& Murata, Miyuki& Kanda, Atsuhiro& Noda, Kosuke…[et al.]. Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1189906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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