![](/images/graphics-bg.png)
Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA)
المؤلفون المشاركون
Cedric, Yamssi
Nkouayep, Vanessa Rosine
Nadia, Noumedem Anangmo Christelle
Raoul, Simeni Njonnou Sylvain
Christian, Ngongang Ouankou
Azizi, Mounvera Abdel
Diane, Gangueu Djape Clotilde
Jeanette, Yondo
Gabriel, Tsila Henri
Mbida, Mpoame
المصدر
Journal of Parasitology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Malaria is one of the most critical diseases causing about 219 million cases worldwide in developing countries.
The spread and development of resistance against chemical antimalarial drugs is one of the major problems associated with malaria control.
The present study was to investigate the antimalarial efficacy of ethyl acetate extract and one fraction of Bidens pilosa in vivo in order to support the usage of this plant by traditional healers to treat malaria.
Methods.
The extracts were prepared by maceration of B.
pilosa leaf powder in ethyl acetate.
The liquid filtrate of the extract and the best in vitro antiplasmodial fraction using HPLC were concentrated and evaporated using a rotavapor under vacuum to dryness.
The antimalarial activity of B.
pilosa plant products were evaluated in vivo against Plasmodium berghei infected mice according to the Peter and Rane test.
The antimalarial efficacy of the a selected crude extract (ethyl acetate extract) was evaluated at 125, 250, and 500 mg/kg, while a selected fraction from ethyl acetate extract (fraction 12) was evaluated at 62.5 and 125 mg/kg.
Blood from experimental animals was collected to assess hematological parameters.
Results.
The crude extract of ethyl acetate and fraction 12 demonstrated 100% in vivo parasite suppressive activity at doses of 500 mg/kg and 125 mg/kg, respectively, for the crude extract and fraction 12.
The mice treated with 250 and 500 mg/kg had their parasitemia (intraerythrocytic phase of P.
Berghei) drop considerably, disappearing by the 8th day in mice receiving 500 mg/kg.
The ethyl acetate extract of B.
pilosa, fraction 12 showed an even higher antiplasmodial activity.
By the 5th day of the experiment, the treatment led to a modification of hematological parameters in mice.
The chloroquine (5 mg/kg), fraction 12 (125 mg/kg), and the crude extract (500 mg/kg) groups all survived the 30 days of the experiment, while the negative control group registered 100% of the deaths.
Conclusion.
This study scientifically supports the use of Bidens pilosa leaves in the traditional treatment of malaria.
However, the mode of action and in vivo toxicity of the plant still need to be assessed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nadia, Noumedem Anangmo Christelle& Cedric, Yamssi& Raoul, Simeni Njonnou Sylvain& Christian, Ngongang Ouankou& Azizi, Mounvera Abdel& Diane, Gangueu Djape Clotilde…[et al.]. 2020. Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA). Journal of Parasitology Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1190120
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nadia, Noumedem Anangmo Christelle…[et al.]. Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA). Journal of Parasitology Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1190120
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nadia, Noumedem Anangmo Christelle& Cedric, Yamssi& Raoul, Simeni Njonnou Sylvain& Christian, Ngongang Ouankou& Azizi, Mounvera Abdel& Diane, Gangueu Djape Clotilde…[et al.]. Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA). Journal of Parasitology Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1190120
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1190120
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)