Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
المؤلفون المشاركون
Alluri, Venkata Krishnaraju
Golakoti, Trimurtulu
Dodda, Sundararaju
Sengupta, Krishanu
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The present communication describes a battery of toxicity studies that include an acute oral toxicity, a subacute twenty-eight-day repeated oral dose toxicity, and genotoxicity studies on a herbal formulation CinDura® (GMCT).
This proprietary herbal composition contains the extracts of the Garcinia mangostana fruit rind (GM) and the Cinnamomum tamala leaf (CT).
The toxicological evaluations were performed following the Organization for Economic Cooperation and Development (OECD) guidelines.
The acute oral toxicity study in Wistar rats suggests that the median lethal dose of CinDura® is at least 2000 mg/kg body weight.
Acute dermal and eye irritation tests in New Zealand white rabbits indicate that the test item is nonirritant to the skin and eyes.
A twenty-eight-day repeated dose oral toxicity study was conducted in male and female Wistar rats using daily doses of 250, 500, and 1000 mg/kg body weight, followed by a fourteen-day reversal period for two satellite groups.
The CinDura®-supplemented animals did not show any sign of toxicity on their body weights, organ weights, and on the hematobiochemical parameters.
The gross pathology and histopathological examinations indicated no treatment-related changes in the experimental animals.
Overall, the no-observed-adverse-effect level (NOAEL) of the herbal blend is 1000 mg/kg body weight, the highest tested dose.
Also, the results of the bacterial reverse mutation test and the erythrocyte micronucleus assay in mouse bone marrow suggest that CinDura® (GMCT) is neither mutagenic nor clastogenic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dodda, Sundararaju& Alluri, Venkata Krishnaraju& Golakoti, Trimurtulu& Sengupta, Krishanu. 2020. Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®). Journal of Toxicology،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1190875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dodda, Sundararaju…[et al.]. Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®). Journal of Toxicology No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1190875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dodda, Sundararaju& Alluri, Venkata Krishnaraju& Golakoti, Trimurtulu& Sengupta, Krishanu. Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®). Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1190875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1190875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر