Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

المؤلفون المشاركون

Nabil, Ahmed
Elshemy, Mohamed M.
Asem, Medhat
Gomaa, Heba F.

المصدر

Journal of Toxicology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-07-15

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage.

Oxidative stress is caused by an imbalance between free radicals’ production and cellular antioxidant defense systems.

In the present study, we investigated the effect of N N′-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl2-) induced renal and hepatic toxicity.

Thirty adult female Sprague Dawley rats were divided into three equal groups: the first group was injected with saline only and served as a control, the second group was injected with HgCl2, and the third group received DPPD + HgCl2 rats injected with HgCl2 without treatment showing a significant increase in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and uric acids compared to control.

Moreover, the second group showed a significant reduction in the activity of the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH)) in addition to a marked increase in the malondialdehyde (MDA) content, histopathological alterations, collagen deposition, CD8%, CD4%, and TGF-β% in kidney and liver tissues compared with the control group.

Treatment with DPPD showed significant recovery (p≤0.001) in all previous parameters and histopathological examination.

In conclusion, we suggested that DPPD may have a promising antioxidant capacity, gives it the applicability to be used as a prophylactic agent against mercury-induced hepatorenal cytotoxicity in the future.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nabil, Ahmed& Elshemy, Mohamed M.& Asem, Medhat& Gomaa, Heba F.. 2020. Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats. Journal of Toxicology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1190894

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nabil, Ahmed…[et al.]. Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats. Journal of Toxicology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1190894

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nabil, Ahmed& Elshemy, Mohamed M.& Asem, Medhat& Gomaa, Heba F.. Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats. Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1190894

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1190894