Toxicological Investigations of Aristolochia longa Root Extracts
المؤلفون المشاركون
Taghzouti, Khalid
Sayah, Karima
El Omari, Nasreddine
El Blidi, Omar
Barkiyou, Malika
Bouyahya, Abdelhakim
Bakrim, Saad
Fettach, Saad
Tahri, Rajae
Chokairi, Omar
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aristolochia longa L.
(Aristolochiaceae) is an herbaceous plant recognized in alternative medicine for its many therapeutic virtues.
The aim of this study was to determine the pharmacotoxicological effects of this plant in order to ensure safe clinical use.
The oral toxicity of the aqueous extract of A.
longa roots was performed in vivo on Wistar rats at doses of 0.8, 1.25, 2, 2.5, and 5 g/kg/day for 21 days.
Clinical signs were observed throughout the experimental period, followed by measurement of body weight change, while selected biochemical parameters, as well as relative organ weights and the histology of liver, kidney, and intestinal tissues, were evaluated after 6, 11, and 16 days and then at the end of 21 days of daily administration.
At repeated doses for 21 days, the extract contributed to significant weight gain, in both control and treated rats.
The global analysis of hepatic and renal biomarkers showed a significant increase between control and different doses of the extract, from the first to the third week of treatment, indicating the likely toxic effect of the extract on liver and kidney function.
Organ toxicity was confirmed by histopathological examination, which revealed greater renal and hepatic parenchymal changes in animals treated with a high dose beyond the 16th day.
At the end of the treatment, relatively small size of intestinal villi was also observed.
It was concluded that ALAE has a low toxicity potential in nonprolonged oral administrations.
However, at high chronic oral doses, A.
longa appears to have significant toxicity on the organs tested.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El Omari, Nasreddine& El Blidi, Omar& Bouyahya, Abdelhakim& Sayah, Karima& Bakrim, Saad& Fettach, Saad…[et al.]. 2020. Toxicological Investigations of Aristolochia longa Root Extracts. Journal of Toxicology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El Omari, Nasreddine…[et al.]. Toxicological Investigations of Aristolochia longa Root Extracts. Journal of Toxicology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1190904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El Omari, Nasreddine& El Blidi, Omar& Bouyahya, Abdelhakim& Sayah, Karima& Bakrim, Saad& Fettach, Saad…[et al.]. Toxicological Investigations of Aristolochia longa Root Extracts. Journal of Toxicology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1190904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1190904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر