Malaria Parasite Density as a Predictor of Hematological Parameter Changes among HIV Infected Adults Attending Two Antiretroviral Treatment Clinics in Kano, Northwest Nigeria
المؤلفون المشاركون
Jegede, Feyisayo E.
Oyeyi, Tinuade I.
Abdulrahman, Surajudeen A.
Mbah, Henry A.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Despite public health significance of dual infections of human immunodeficiency virus (HIV) and malaria in developing countries like Nigeria, information on the association between malaria parasite density count (MPDC) and hematological parameter changes among HIV-infected individuals is rarely available.
Objectives.
To evaluate burden of HIV and malaria dual infections and assess the predictive association of MPDC with hematological parameter changes among HIV infected adults attending two antiretroviral treatment clinics in Kano, Nigeria.
Methodology.
This was a cross-sectional study consisting of 1521 consented participants randomly selected between June 2015 and May 2016.
Participants’ basic characteristics and clinical details were collected using a pretested and validated standardized questionnaire.
Collected venous blood was analyzed for malaria by rapid testing and microscopy including malaria parasite density; hematological parameters were estimated using a Sysmex XP-300 autoanalyzer.
Data was reviewed, cleaned, and analyzed using SPSS software version 23.0.
Mean hematological parameters and HIV/malaria status were compared using the independent t-test; hematological parameters and MPDC relationship was tested by simple linear regression analysis.
Statistically significant difference at probability of <0.05 was considered for all variables.
Results.
The majority (70.6%) of the participants were females.
Mean (SD) age was 37.30 ± (10.41) years and ranged from 18 to 78 years.
25.4% of participants had dual infection, 99% due to Plasmodium falciparum species.
Mean MPDC was 265 ± 31.8 (SD) cells/μl and ranged from 20 to 2500 cells/μl.
Dual infection was highest (37.5%) among respondents in the age group ≥60 years.
Prevalence was similar among other age groups (p=0.165) and gender (p=0.942).
Of the 16 hematological parameters evaluated, 11 showed significant difference between HIV mono-infected and dual infected participants.
Of the 11 parameters, only 7 (Hb, MCHC, red cells count, neutrophil and lymphocyte percentage, absolute lymphocyte count, and red cell distribution width) were significantly predictive of changes with respect to MPDC.
Conclusions.
MPDC was significantly predictive of changes in 7 hematological parameters among dual infected participants in these settings.
In routine malaria diagnosis, MPDC determination with respect to changes in some hematological parameters should be considered in ART programs for improved patient management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jegede, Feyisayo E.& Oyeyi, Tinuade I.& Abdulrahman, Surajudeen A.& Mbah, Henry A.. 2020. Malaria Parasite Density as a Predictor of Hematological Parameter Changes among HIV Infected Adults Attending Two Antiretroviral Treatment Clinics in Kano, Northwest Nigeria. Journal of Tropical Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191273
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jegede, Feyisayo E.…[et al.]. Malaria Parasite Density as a Predictor of Hematological Parameter Changes among HIV Infected Adults Attending Two Antiretroviral Treatment Clinics in Kano, Northwest Nigeria. Journal of Tropical Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191273
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jegede, Feyisayo E.& Oyeyi, Tinuade I.& Abdulrahman, Surajudeen A.& Mbah, Henry A.. Malaria Parasite Density as a Predictor of Hematological Parameter Changes among HIV Infected Adults Attending Two Antiretroviral Treatment Clinics in Kano, Northwest Nigeria. Journal of Tropical Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191273
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191273
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر