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Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys of Plasmodium berghei-Infected Mice
المؤلفون المشاركون
Na-Ek, Prasit
Punsawad, Chuchard
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Acute kidney injury (AKI) is one of the most serious complications of severe Plasmodium falciparum malaria, but the exact pathogenic mechanisms of AKI in P.
falciparum infection have not been clearly elucidated.
We hypothesized that oxidative stress is a potential mediator of acute tubular necrosis in P.
falciparum-infected kidneys.
Therefore, this study aimed to investigate the histopathological changes and markers of oxidative stress in kidney tissues from mice with experimental malaria.
DBA/2 mice were divided into two groups: the mice in the malaria-infected group (n = 10) were intraperitoneally injected with 1 × 106P.
berghei ANKA-infected red blood cells, and the mice in the control group (n = 10) were intraperitoneally injected with a single dose of 0.85% normal saline.
Kidney sections were collected and used for histopathological examination and the investigation of 4-hydroxynonenal (4-HNE) and heme oxygenase-1 (HO-1) expression through immunohistochemistry staining.
The histopathology study revealed that the P.
berghei-infected kidneys exhibited a greater area of tubular necrosis than those of the control group (p<0.05).
The positive staining scores for 4-HNE and HO-1 expression in tubular epithelial cells of the P.
berghei-infected group were significantly higher than those found for the control group (p<0.05).
In addition, significant positive correlations were found between the tubular necrosis score and the positive staining scores for 4-HNE and HO-1 in the kidneys from the P.
berghei-infected group.
In conclusion, this finding demonstrates that increased expression of 4-HNE and HO-1 might be involved in the pathogenesis of acute tubular damage in the kidneys during malaria infection.
Our results provide new insights into the pathogenesis of malaria-associated AKI and might provide guidelines for the future development of a therapeutic intervention for malaria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Na-Ek, Prasit& Punsawad, Chuchard. 2020. Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys of Plasmodium berghei-Infected Mice. Journal of Tropical Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Na-Ek, Prasit& Punsawad, Chuchard. Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys of Plasmodium berghei-Infected Mice. Journal of Tropical Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Na-Ek, Prasit& Punsawad, Chuchard. Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys of Plasmodium berghei-Infected Mice. Journal of Tropical Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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