Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study
المؤلفون المشاركون
Dai, Guangming
Chen, Xingru
Ran, Yajuan
Peng, Junnan
Li, Xinglong
Deng, Huojin
Zhu, Tao
Xiao, Min
Wang, Jiajia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Rationale.
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is highly heterogeneous with a plethora of different etiologic factors and inflammatory presentations.
COPD with higher blood eosinophil count is associated with increased readmission rates and better corticosteroid responses.
However, the clinical features of eosinophilic AECOPD are not well explored.
Thus, this study was aimed at exploring the clinical differences between eosinophilic and noneosinophilic AECOPD.
Methods.
A total of 643 AECOPD patients were enrolled in this multicenter cross-sectional study.
Finally, 455 were included, 214 in the normal-eosinophil AECOPD (NEOS-AECOPD) group, 63 in the mild increased-eosinophil AECOPD (MEOS-AECOPD) group, and 138 in the severe increased-eosinophil AECOPD (SEOS-AECOPD) group.
Demographic data, underlying diseases, symptoms, and laboratory findings were collected.
Multiple logistic regression analysis was performed to identify the independent factors associated with blood eosinophils (EOS).
Correlations between blood EOS and its associated independent factors were evaluated.
Results.
The significant differences in 19 factors, including underlying diseases, clinical symptoms, and laboratory parameters, were identified by univariate analysis.
Subsequently, multiple logistic regression analysis revealed that lymphocyte%, neutrophil% (NS%), procalcitonin (PCT), and anion gap (AG) were independently associated with blood EOS in AECOPD.
Both blood EOS counts and EOS% were significantly correlated with lymphocyte%, NS%, PCT, and AG.
Conclusions.
Collectively, blood EOS was independently associated with lymphocyte%, NS%, PCT, and AG in AECOPD patients.
Lymphocyte% was lower, and NS%, PCT, and AG were higher in eosinophilic AECOPD.
Our results indicate that viral-dominant infections are the probable major etiologies of eosinophilic AECOPD.
Noneosinophilic AECOPD is more likely associated with bacterial-dominant infections.
The systemic inflammation in noneosinophilic AECOPD was more severe.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dai, Guangming& Ran, Yajuan& Wang, Jiajia& Chen, Xingru& Peng, Junnan& Li, Xinglong…[et al.]. 2020. Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Guangming…[et al.]. Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dai, Guangming& Ran, Yajuan& Wang, Jiajia& Chen, Xingru& Peng, Junnan& Li, Xinglong…[et al.]. Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر