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PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation
المؤلفون المشاركون
Corsi Romanelli, Massimiliano M.
Vianello, Elena
Tacchini, Lorenza
Macchi, Chiara
Sitzia, Clementina
Ruscica, Massimiliano
Schmitz, Gerd
Dozio, Elena
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced.
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a proinflammatory mediator involved in atherosclerosis, is also produced by visceral fat.
Due to the correlation of inflammation with PCSK9 and EAT enlargement, we evaluated whether PCSK9 was expressed in EAT and associated with EAT inflammation and volume.
EAT samples were isolated during surgery.
EAT thickness was measured by echocardiography.
A microarray was used to explore EAT transcriptoma.
The PCSK9 protein levels were measured by Western Blot in EAT and ELISA in plasma.
PCSK9 was expressed at both the gene and protein levels in EAT.
We found a positive association with EAT thickness and local proinflammatory mediators, in particular, chemokines for monocytes and lymphocytes.
No association was found with the circulating PCSK9 level.
The expression of PCSK9 in EAT argues that PCSK9 is part of the EAT secretome and EAT inflammation is associated with local PCSK9 expression, regardless of circulating PCSK9 levels.
Whether reducing EAT inflammation or PCSK9 local levels may have beneficial effects on EAT metabolism and cardiovascular risk needs further investigations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dozio, Elena& Ruscica, Massimiliano& Vianello, Elena& Macchi, Chiara& Sitzia, Clementina& Schmitz, Gerd…[et al.]. 2020. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191501
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dozio, Elena…[et al.]. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191501
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dozio, Elena& Ruscica, Massimiliano& Vianello, Elena& Macchi, Chiara& Sitzia, Clementina& Schmitz, Gerd…[et al.]. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191501
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191501
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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