Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis
المؤلفون المشاركون
Liu, Heliang
Ma, Jingjing
Jiang, Tian
Li, Enhong
Zhao, Xiaokun
Wang, Ying
Cui, Jie
Hao, Xiaohui
Guo, Lingli
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue.
Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases.
However, no data on the possible relationship between sRAGE and inflammation of silicosis are available.
In this study, serum from subjects with silicosis (n=59) or from healthy controls (HC, n=14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and oxidized low-density lipoprotein (ox-LDL).
The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson’s correlation analyses.
Mean levels of serum sRAGE were lower in silicosis than those in controls (p<0.05).
The subjects who had a longer term of occupational exposure had higher levels of sRAGE (p<0.05).
The secretion of TNF-α, IL-1β, IL-6, TGF-β1, and ox-LDL was significantly higher in the silicosis group than that in the HC group (p<0.05).
Furthermore, the levels of sRAGE were negatively correlated with TNF-α, IL-6, IL-1β, and ox-LDL.
There is no correlation between sRAGE and TGF-β1 and lung function.
The optimal point of sRAGE for differentiating silicosis from healthy controls was 14250.02 pg/ml by ROC curve analysis.
A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Heliang& Ma, Jingjing& Jiang, Tian& Li, Enhong& Zhao, Xiaokun& Wang, Ying…[et al.]. 2020. Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191594
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Heliang…[et al.]. Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191594
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Heliang& Ma, Jingjing& Jiang, Tian& Li, Enhong& Zhao, Xiaokun& Wang, Ying…[et al.]. Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191594
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191594
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر