RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis
المؤلفون المشاركون
Liang, Li
Wang, Yan
Zhang, Zhenzhen
Qu, Aijuan
Wang, Hua
Xie, Guomin
Liu, Hui
Pan, Jing
Cheng, Hao
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alcoholic cirrhosis is an end-stage liver disease with impaired survival and often requires liver transplantation.
Recent data suggests that receptor-interacting protein kinase-3- (RIPK3-) mediated necroptosis plays an important role in alcoholic cirrhosis.
Additionally, neutrophil infiltration is the most characteristic pathologic hallmark of alcoholic hepatitis.
Whether RIPK3 level is correlated with neutrophil infiltration or poor prognosis in alcoholic cirrhotic patients is still unknown.
We aimed to determine the correlation of RIPK3 and neutrophil infiltration with the prognosis in the end-stage alcoholic cirrhotic patients.
A total of 20 alcoholic cirrhotic patients subjected to liver transplantation and 5 normal liver samples from control patients were retrospectively enrolled in this study.
Neutrophil infiltration and necroptosis were assessed by immunohistochemical staining for myeloperoxidase (MPO) and RIPK3, respectively.
The noninvasive score system (model for end-stage liver disease (MELD)) and histological score systems (Ishak, Knodell, and ALD grading and ALD stage) were used to evaluate the prognosis.
Neutrophil infiltration was aggravated in patients with a high MELD score (≥32) in the liver.
The MPO and RIPK3 levels in the liver were positively related to the Ishak score.
The RIPK3 was also significantly and positively related to the Knodell score.
In conclusion, RIPK3-mediated necroptosis and neutrophil-mediated alcoholic liver inflammatory response are highly correlated with poor prognosis in patients with end-stage alcoholic cirrhosis.
RIPK3 and MPO might serve as potential predictors for poor prognosis in alcoholic cirrhotic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhenzhen& Xie, Guomin& Liang, Li& Liu, Hui& Pan, Jing& Cheng, Hao…[et al.]. 2018. RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhenzhen…[et al.]. RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1191614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhenzhen& Xie, Guomin& Liang, Li& Liu, Hui& Pan, Jing& Cheng, Hao…[et al.]. RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر