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Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway
المؤلفون المشاركون
Lu, Yin
Zänker, Kurt
Wang, Aiyun
Chen, Wenxing
Wu, Yuanyuan
Ding, Yushi
Yu, Suyun
Wei, Zhonghong
Deng, Rui
Chen, Peng
Sun, Yifan
Jia, Qi
Li, Xiaoman
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-15
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Relieving Sore Throat Formula (RSTF) is a formula approved by the China Food and Drug Administration and has been used for the treatment of pharyngitis in clinic for many years.
However, the potential pharmacological mechanism still remains unknown.
We combined multiple methods including bioinformatics data digging, network pharmacology analysis, and pathway analysis to predict the potential target of RSTF.
We verified our in silico prediction results with an in vivo/vitro antibacterial effect test, mouse phagocytic index test, proliferation, transformation, and migration of mouse spleen lymphocytes.
Alteration of NF-κB pathway was determined by Western blotting, immunofluorescence, and PCR.
The in vivo experiments demonstrated that the RSTF could significantly relieve the symptoms of pharyngitis.
A rat saliva secretion test showed that RSTF can effectively relieve the xerostomia symptom.
A phenol red excretion test showed that RSTF has an eliminating phlegm effect.
A hot plate method and granuloma experiment proved that RSTF also have analgesic and anti-inflammatory effects.
In silico prediction demonstrates that 70 active compounds of RSTF were filtered out through ADME screening and 84 putative targets correlated with different diseases.
Pathway enrichment analysis showed that the candidate targets were mostly related to the response to bacteria and immunity signalling pathways, which are known contributors to pharyngitis.
Experimental results confirmed that RSTF exerted therapeutic effects on pharyngitis mainly by antibacterial effect and downregulation of NF-κB activities.
It is demonstrated both in silico and in vivo/vitro that RSTF exerted therapeutic effects on pharyngitis mainly through an antibiotic effect and downregulation of NF-κB signalling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Yushi& Yu, Suyun& Wei, Zhonghong& Deng, Rui& Chen, Peng& Sun, Yifan…[et al.]. 2020. Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1191617
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Yushi…[et al.]. Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1191617
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Yushi& Yu, Suyun& Wei, Zhonghong& Deng, Rui& Chen, Peng& Sun, Yifan…[et al.]. Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1191617
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191617
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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