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Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages
المؤلفون المشاركون
Park, Yea-Jin
Cheon, Se-Yun
Lee, Dong-Sung
Cominguez, Divina C.
Zhang, Zhiyun
Lee, Sangwoo
An, Hyo-Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
A hypernomic reaction or an abnormal inflammatory process could cause a series of diseases, such as cardiovascular disease, neurodegeneration, and cancer.
Additionally, oxidative stress has been identified to induce severe tissue injury and inflammation.
Carpesium cernuum L.
(C.
cernuum) is a Chinese folk medicine used for its anti-inflammatory, analgesic, and detoxifying properties.
However, the underlying molecular mechanism of C.
cernuum in inflammatory and oxidative stress conditions remains largely unknown.
The aim of this study was to examine the effects of a methanolic extract of C.
cernuum (CLME) on lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages and a sepsis mouse model.
The data presented in this study indicated that CLME inhibited LPS-induced production of proinflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 cells.
CLME treatment also reduced reactive oxygen species (ROS) generation and enhanced the expression of heme oxygenase-1 (HO-1) protein in a dose-dependent manner in the LPS-stimulated RAW 264.7 cells.
Moreover, CLME treatment abolished the nuclear translocation of nuclear factor-κB (NF-κB), enhanced the activation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), and reduced the expression of extracellular signal-related kinase (ERK) and ERK kinase (MEK) phosphorylation in LPS-stimulated RAW 264.7 cells.
These outcomes implied that CLME could be a potential antioxidant and anti-inflammatory agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Yea-Jin& Cheon, Se-Yun& Lee, Dong-Sung& Cominguez, Divina C.& Zhang, Zhiyun& Lee, Sangwoo…[et al.]. 2020. Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1191633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Yea-Jin…[et al.]. Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages. Mediators of Inflammation No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1191633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Yea-Jin& Cheon, Se-Yun& Lee, Dong-Sung& Cominguez, Divina C.& Zhang, Zhiyun& Lee, Sangwoo…[et al.]. Anti-Inflammatory and Antioxidant Effects of Carpesium cernuum L. Methanolic Extract in LPS-Stimulated RAW 264.7 Macrophages. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1191633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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