Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD
المؤلفون المشاركون
Oliver, Brian G.
Jian-sheng, Li
Ya, Li
Tian, Yange
Zhao, Peng
Liu, Xuefang
Wang, Jing
He, Huihui
Jia, Rui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD).
The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood.
In this study, we aimed to investigate the effect of PM2.5 on lung injury in rats with hallmark features of COPD.
Cardinal features of human COPD were induced in a rat model by repeated cigarette smoke inhalation and bacterial infection for 8 weeks.
Then, from week 9 to week 16, some of these rats with COPD were subjected to real-time concentrated atmospheric PM2.5.
Lung function, pathology, inflammatory cytokines, oxidative stress, and mucus and collagen production were measured.
As expected, the COPD rats had developed emphysema, inflammation, and deterioration in lung function.
PM2.5 exposure resulted in greater lung function decline and histopathological changes, as reflected by increased Mucin (MUC) 5ac, MUC5b, Collagen I, Collagen III, and the profibrotic cytokine α-smooth muscle-actin (SMA), transforming growth factor- (TGF-) β1 in lung tissues.
PM2.5 also aggravated inflammation, increasing neutrophils and eosinophils in bronchoalveolar lavage fluid (BALF) and cytokines including Interleukin- (IL-) 1β, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-4.
The likely mechanism is through oxidative stress as antioxidants levels were decreased, whereas oxidants were increased, indicating a detrimental shift in the oxidant-antioxidant balance.
Altogether, these results suggest that PM2.5 exposure could promote the development of COPD by impairing lung function and exacerbating pulmonary injury, and the potential mechanisms are related to inflammatory response and oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jing& Ya, Li& Zhao, Peng& Tian, Yange& Liu, Xuefang& He, Huihui…[et al.]. 2020. Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191737
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jing…[et al.]. Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191737
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jing& Ya, Li& Zhao, Peng& Tian, Yange& Liu, Xuefang& He, Huihui…[et al.]. Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191737
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191737
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر