Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome
المؤلفون المشاركون
Tanase, Cristiana Pistol
Albulescu, Lucian
Mihai, Simona
Popescu, Ionela Daniela
Anton, Gabriela
Mambet, Cristina
Enciu, Ana-Maria
Necula, Laura Georgiana
Codrici, Elena
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-06
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Persistent, low-grade inflammation is now considered a hallmark feature of chronic kidney disease (CKD), being involved in the development of all-cause mortality of these patients.
Although substantial improvements have been made in clinical care, CKD remains a major public health burden, affecting 10–15% of the population, and its prevalence is constantly growing.
Due to its insidious nature, CKD is rarely diagnosed in early stages, and once developed, its progression is unfortunately irreversible.
There are many factors that contribute to the setting of the inflammatory status in CKD, including increased production of proinflammatory cytokines, oxidative stress and acidosis, chronic and recurrent infections, altered metabolism of adipose tissue, and last but not least, gut microbiota dysbiosis, an underestimated source of microinflammation.
In this scenario, a huge step forward was made by the increasing progression of omics approaches, specially designed for identification of biomarkers useful for early diagnostic and follow-up.
Recent omics advances could provide novel insights in deciphering the disease pathophysiology; thus, identification of circulating biomarker panels using state-of-the-art proteomic technologies could improve CKD early diagnosis, monitoring, and prognostics.
This review aims to summarize the recent knowledge regarding the relationship between inflammation and CKD, highlighting the current proteomic approaches, as well as the inflammasomes and gut microbiota dysbiosis involvement in the setting of CKD, culminating with the troubling bidirectional connection between CKD and renal malignancy, raised on the background of an inflammatory condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mihai, Simona& Codrici, Elena& Popescu, Ionela Daniela& Enciu, Ana-Maria& Albulescu, Lucian& Necula, Laura Georgiana…[et al.]. 2018. Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1191750
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mihai, Simona…[et al.]. Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome. Journal of Immunology Research No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1191750
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mihai, Simona& Codrici, Elena& Popescu, Ionela Daniela& Enciu, Ana-Maria& Albulescu, Lucian& Necula, Laura Georgiana…[et al.]. Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1191750
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191750
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر