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Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal IschemiaReperfusion Injury in Rats through NF-κBNLRP3 Pathway
المؤلفون المشاركون
Yang, Ling
Guo, Yan
Fan, Xin
Chen, Ye
Yang, Bo
Liu, Ke-Xuan
Zhou, Jun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Intestinal ischemia/reperfusion (I/R) injury often causes inflammatory responses and coagulation disorders, which is further promoting the deterioration of the disease.
Hydrogen has anti-inflammatory, antioxidative, and antiapoptotic properties against various diseases.
However, the effect of hydrogen on coagulation dysfunction after intestinal I/R and the underlying mechanism remains unclear.
The purpose of this study was to explore whether hydrogen-rich solution (HRS) could attenuate coagulation disorders and inflammation to improve intestinal injury and poor survival following intestinal I/R.
The rat model of intestinal I/R injury was established by clamping the superior mesenteric artery for 90 min and reperfusion for 2 h.
HRS (10 or 20 mL/kg) or 20 mL/kg 0.9% normal saline was intravenously injected at 10 min before reperfusion, respectively.
The samples were harvested at 2 h after reperfusion for further analyses.
Moreover, the survival rate was observed for 24 h.
The results showed that HRS improved the survival rate and alleviated serum diamine oxidase activities, intestinal injury, edema, and apoptosis.
Interestingly, HRS markedly improved intestinal I/R-mediated coagulation disorders as evidenced by abnormal conventional indicators of coagulation and thromboelastography.
Additionally, HRS attenuated inflammatory responses and the elevated tissue factor (TF) and inhibited nuclear factor kappa beta (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in peripheral blood mononuclear cells.
Moreover, inflammatory factors and myeloperoxidase were closely associated with TF level.
This study thus emphasized upon the amelioration of coagulation disorders and inflammation by HRS as a mechanism to improve intestinal I/R-induced intestinal injury and poor survival, which might be partially related to inhibition of NF-κB/NLRP3 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Ling& Guo, Yan& Fan, Xin& Chen, Ye& Yang, Bo& Liu, Ke-Xuan…[et al.]. 2020. Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal IschemiaReperfusion Injury in Rats through NF-κBNLRP3 Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Ling…[et al.]. Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal IschemiaReperfusion Injury in Rats through NF-κBNLRP3 Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Ling& Guo, Yan& Fan, Xin& Chen, Ye& Yang, Bo& Liu, Ke-Xuan…[et al.]. Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal IschemiaReperfusion Injury in Rats through NF-κBNLRP3 Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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