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Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia
المؤلفون المشاركون
Lima, Tamires Cardoso
Dalmarco, Eduardo
de Campos Facchin, Bruno Matheus
da Rosa, Julia Salvan
Luz, Ana Beatriz Gobbo
Moon, Yeo Jim Kinoshita
Casoti, Rosana
Biavatti, Maique Weber
Fröde, Tânia Silvia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from Calea pinnatifida leaves in a mouse model of pulmonary neutrophilia.
Methods.
The CE and derived fractions, hexane, ethyl acetate, and methanol, were obtained from C.
pinnatifida leaves.
The compounds 3,5- and 4,5-di-O-E-caffeoylquinic acids were isolated from the EtOAc fraction using chromatography and were identified using infrared spectroscopic data and nuclear magnetic resonance (1H and 13C NMR).
Leukocytes count, protein concentration of the exudate, myeloperoxidase (MPO) and adenosine deaminase (ADA), and nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1-beta (IL-1β), and interleukin-17A (IL-17A) levels were determined in the pleural fluid leakage after 4 h of pleurisy induction.
We also analyzed the effects of isolated compounds on the phosphorylation of both p65 and p38 in the lung tissue.
Results.
The CE, its fractions, and isolated compounds inhibited leukocyte activation, protein concentration of the exudate, and MPO, ADA, NOx, TNF-α, IL-1β, and IL-17A levels.
3,5- and 4,5-di-O-E-caffeoylquinic acids also inhibited phosphorylation of both p65 and p38 (P<0.05).
Conclusion.
This study demonstrated that C.
pinnatifida presents important anti-inflammatory properties by inhibiting activated leukocytes and protein concentration of the exudate.
These effects were related to the inhibition of proinflammatory mediators.
The dicaffeoylquinic acids may be partially responsible for these anti-inflammatory properties through the inhibition of nuclear transcription factor kappa B and mitogen-activated protein kinase pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Campos Facchin, Bruno Matheus& da Rosa, Julia Salvan& Luz, Ana Beatriz Gobbo& Moon, Yeo Jim Kinoshita& Lima, Tamires Cardoso& Casoti, Rosana…[et al.]. 2020. Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191767
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Campos Facchin, Bruno Matheus…[et al.]. Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191767
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Campos Facchin, Bruno Matheus& da Rosa, Julia Salvan& Luz, Ana Beatriz Gobbo& Moon, Yeo Jim Kinoshita& Lima, Tamires Cardoso& Casoti, Rosana…[et al.]. Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191767
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191767
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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