Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model
المؤلفون المشاركون
Rodriguez-Canales, Mario
Canales-Martinez, Maria Margarita
Rodriguez-Monroy, Marco Aurelio
Martinez-Galero, Elizdath
Nava-Torres, Alma D.
Garduño-Siciliano, Leticia
Terrazas, Luis I.
Sánchez-Torres, Luvia Enid
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cyrtocarpa procera is a plant used in traditional Mexican medicine to treat different gastrointestinal problems.
Here, we investigated the effects of a C.
procera methanolic extract in DSS-induced colitis mice.
Ulcerative colitis (UC) was induced by administering 4% DSS in drinking water to female BALB/c mice.
Compared to untreated mice with UC, the treatment group receiving the C.
procera extract presented less severe UC symptoms of diarrhea, bleeding, and weight loss.
Additionally, colon shortening was significantly reduced, and at the microscopic level, only minor damage was observed.
Levels of proinflammatory cytokines such as TNF-α, IL-1β, and IFNγ in serum as well as the MPO activity in the colon were significantly reduced in the C.
procera methanolic extract-treated group.
Moreover, the extract of C.
procera reduced oxidative stress during UC, preventing the deterioration of the activity of antioxidant enzymes such as SOD, CAT, and GPx.
Additionally, the extract decreased lipid peroxidation damage and its final products, such as malondialdehyde (MDA).
In agreement with this, in vitro assays with the C.
procera extract displayed good antioxidant capacity, probably due to the presence of polyphenolic compounds, in particular the flavonoids that were identified, such as chrysin, naringenin, kaempferol, and catechin, which have been reported to have anti-inflammatory and antioxidant activities.
Therefore, the improvement of UC by the C.
procera methanolic extract may be related to the action mechanisms of these compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez-Canales, Mario& Martinez-Galero, Elizdath& Nava-Torres, Alma D.& Sánchez-Torres, Luvia Enid& Garduño-Siciliano, Leticia& Canales-Martinez, Maria Margarita…[et al.]. 2020. Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez-Canales, Mario…[et al.]. Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez-Canales, Mario& Martinez-Galero, Elizdath& Nava-Torres, Alma D.& Sánchez-Torres, Luvia Enid& Garduño-Siciliano, Leticia& Canales-Martinez, Maria Margarita…[et al.]. Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر