Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis
المؤلفون المشاركون
García-Laorden, M. Isabel
Rodríguez-González, Raquel
Martín-Barrasa, José L.
García-Hernández, Sonia
Ramos-Nuez, Ángela
González-García, H. Celeste
González-Martín, Jesús M.
Kacmarek, Robert M.
Villar, Jesús
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Supplemental oxygen is a supportive treatment in patients with sepsis to balance tissue oxygen delivery and demand in the tissues.
However, hyperoxia may induce some pathological effects.
We sought to assess organ damage associated with hyperoxia and its correlation with the production of reactive oxygen species (ROS) in a preclinical model of intra-abdominal sepsis.
For this purpose, sepsis was induced in male, Sprague-Dawley rats by cecal ligation and puncture (CLP).
We randomly assigned experimental animals to three groups: control (healthy animals), septic (CLP), and sham-septic (surgical intervention without CLP).
At 18 h after CLP, septic (n=39), sham-septic (n=16), and healthy (n=24) animals were placed within a sealed Plexiglas cage and randomly distributed into four groups for continuous treatment with 21%, 40%, 60%, or 100% oxygen for 24 h.
At the end of the experimental period, we evaluated serum levels of cytokines, organ damage biomarkers, histological examination of brain and lung tissue, and ROS production in each surviving animal.
We found that high oxygen concentrations increased IL-6 and biomarkers of organ damage levels in septic animals, although no relevant histopathological lung or brain damage was observed.
Healthy rats had an increase in IL-6 and aspartate aminotransferase at high oxygen concentration.
IL-6 levels, but not ROS levels, are correlated with markers of organ damage.
In our study, the use of high oxygen concentrations in a clinically relevant model of intra-abdominal sepsis was associated with enhanced inflammation and organ damage.
These findings were unrelated to ROS release into circulation.
Hyperoxia could exacerbate sepsis-induced inflammation, and it could be by itself detrimental.
Our study highlights the need of developing safer thresholds for oxygen therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García-Laorden, M. Isabel& Rodríguez-González, Raquel& Martín-Barrasa, José L.& García-Hernández, Sonia& Ramos-Nuez, Ángela& González-García, H. Celeste…[et al.]. 2020. Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García-Laorden, M. Isabel…[et al.]. Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García-Laorden, M. Isabel& Rodríguez-González, Raquel& Martín-Barrasa, José L.& García-Hernández, Sonia& Ramos-Nuez, Ángela& González-García, H. Celeste…[et al.]. Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر