Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization
المؤلفون المشاركون
Dominioni, Lorenzo
Imperatori, Andrea
Noonan, D.
Bosi, Annalisa
Bassani, Barbara
Bruno, Antonino
Zanellato, Silvia
Albini, Adriana
Musco, Alessandra
Cattoni, Maria
Desio, Matteo
Nardecchia, Elisa
D’Urso, Davide Giuseppe
Mortara, Lorenzo
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-29
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Natural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired in cancer patients, becoming poorly cytotoxic.
A particular type of NK cells, from the decidua, has low cytotoxicity and shows proangiogenic functions.
We investigated whether NK cells from peripheral blood (PB) and pleural effusions of patients develop decidual-like NK phenotype and whether exposure to IL-2 can restore their killing ability in the presence of pleural fluids.
NK cells from pleural effusion of patients with inflammatory conditions (iPE, n = 18), primary tumor (ptPE, n = 18), and metastatic tumor (tmPE, n = 27) acquired the CD56brightCD16− phenotype.
NK cells from both ptPE and tmPE showed increased expression for the CD49a and CD69 decidual-like (dNK) markers and decreased levels of the CD57 maturation marker.
NK from all the PE analyzed showed impaired degranulation capability and reduced perforin release.
PE-NK cells efficiently responded to IL-2 stimulation in vitro.
Addition of TGFβ or cell-free pleural fluid to IL-2 in the culture medium abrogated NK cell CD107a and IFNγ expression even in healthy donors (n = 14) NK.
We found that tmPE-NK cells produce VEGF and support the formation of capillary-like structures in endothelial cells.
Our results suggest that the PE tumor microenvironment can shape NK cell polarization towards a low cytotoxic, decidual-like, highly proangiogenic phenotype and that IL-2 treatment is not sufficient to limit this process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bosi, Annalisa& Zanellato, Silvia& Bassani, Barbara& Albini, Adriana& Musco, Alessandra& Cattoni, Maria…[et al.]. 2018. Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1191807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bosi, Annalisa…[et al.]. Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1191807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bosi, Annalisa& Zanellato, Silvia& Bassani, Barbara& Albini, Adriana& Musco, Alessandra& Cattoni, Maria…[et al.]. Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1191807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر