OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics

المؤلفون المشاركون

Sprangers, Ben
Herman, Jean
Waer, Mark
Louat, Thierry
Van Belle, Kristien

المصدر

Journal of Immunology Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-09-12

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

B cells are pathogenic in various disease processes and therefore represent an interesting target for the development of novel immunosuppressants.

In the search for new therapeutic molecules, we utilized an in vitro B cell activation assay with ODN2006-stimulated Namalwa cells to screen a chemical library of small molecules for B cell modulating effects.

OSU-T315, described as an inhibitor of integrin-linked kinase (ILK), was hereby identified as a hit.

On human and murine primary B cells, OSU-T315 potently suppressed the proliferation and the production of antibodies and cytokines upon stimulation, suggesting that ILK could be a promising target in the modulation of B cell activity.

Mice with B cell-specific knockout of ILK were generated.

Surprisingly, knockout of ILK in murine B cells did not affect B cell function as assessed by several in vivo and ex vivo B cell assays and did not alter the B cell immunosuppressive activity of OSU-T315.

In conclusion, OSU-T315 displays potency as B cell modulator, probably through a mechanism of action independent of ILK, and might serve as lead drug molecule for the development of novel B cell-selective drugs.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Van Belle, Kristien& Herman, Jean& Waer, Mark& Sprangers, Ben& Louat, Thierry. 2018. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1191840

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Van Belle, Kristien…[et al.]. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1191840

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Van Belle, Kristien& Herman, Jean& Waer, Mark& Sprangers, Ben& Louat, Thierry. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1191840

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1191840