OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics
المؤلفون المشاركون
Sprangers, Ben
Herman, Jean
Waer, Mark
Louat, Thierry
Van Belle, Kristien
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
B cells are pathogenic in various disease processes and therefore represent an interesting target for the development of novel immunosuppressants.
In the search for new therapeutic molecules, we utilized an in vitro B cell activation assay with ODN2006-stimulated Namalwa cells to screen a chemical library of small molecules for B cell modulating effects.
OSU-T315, described as an inhibitor of integrin-linked kinase (ILK), was hereby identified as a hit.
On human and murine primary B cells, OSU-T315 potently suppressed the proliferation and the production of antibodies and cytokines upon stimulation, suggesting that ILK could be a promising target in the modulation of B cell activity.
Mice with B cell-specific knockout of ILK were generated.
Surprisingly, knockout of ILK in murine B cells did not affect B cell function as assessed by several in vivo and ex vivo B cell assays and did not alter the B cell immunosuppressive activity of OSU-T315.
In conclusion, OSU-T315 displays potency as B cell modulator, probably through a mechanism of action independent of ILK, and might serve as lead drug molecule for the development of novel B cell-selective drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Van Belle, Kristien& Herman, Jean& Waer, Mark& Sprangers, Ben& Louat, Thierry. 2018. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1191840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Van Belle, Kristien…[et al.]. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1191840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Van Belle, Kristien& Herman, Jean& Waer, Mark& Sprangers, Ben& Louat, Thierry. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1191840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر