Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C
المؤلفون المشاركون
Ramalho, Leandra Naira Zambelli
da Silva, Deisy Mara
Dias, Fabrício C.
Araújo, Roberta C.
Bertol, Bruna C.
Almeida, Patrícia H.
Teixeira, Andreza C.
Souza, Fernanda F.
Villanova, Marcia G.
Martinelli, Ana L. C.
Donadi, Eduardo Antônio
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective.
Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease.
This study aimed to evaluate the expression of HLA-E in the liver and its association with the severity of liver disease in HCV patients.
We performed a retrospective analysis of liver biopsies from 125 HCV patients and from 20 control subjects without liver disease.
Liver biopsies were reviewed and classified according to severity of fibrosis and inflammatory activity.
The pathologist assessed the magnitude of HLA-E expression in a semiquantitative way, attributing scores from 0 to 3.
Immunohistochemistry showed positive for HLA-E in hepatocyte and Kupffer cells.
The rate of HLA-E positivity in hepatocytes and Kupffer cells was significantly higher in HCV patients compared to controls.
The liver samples classified as severe fibrosis and necroinflammatory activity presented greater expression of HLA-E on Kupffer cells and hepatocytes, with a significant linear association.
It indicates that HLA-E expression may have an immunomodulatory effect and a possible role in the severity of liver disease in chronic hepatitis C.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Araújo, Roberta C.& Dias, Fabrício C.& Bertol, Bruna C.& da Silva, Deisy Mara& Almeida, Patrícia H.& Teixeira, Andreza C.…[et al.]. 2018. Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1191844
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Araújo, Roberta C.…[et al.]. Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1191844
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Araújo, Roberta C.& Dias, Fabrício C.& Bertol, Bruna C.& da Silva, Deisy Mara& Almeida, Patrícia H.& Teixeira, Andreza C.…[et al.]. Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1191844
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191844
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر