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Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients
المؤلفون المشاركون
Faure, Christophe
Samarani, Suzanne
Sagala, Patrick
Jantchou, Prevost
Grimard, Guy
Deslandres, Colette
Amre, Devendra K.
Ahmad, Ali
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients.
For this purpose, we compared the expression of different activating and inhibitory receptors (KIR and non-KIR) and integrins on NK cells as well as their recent degranulation history between the patients and age-matched healthy controls.
The study was conducted using freshly obtained peripheral blood samples from the study participants.
Multiple color flow cytometry was used for these determinations.
Our results show that NK cells from treatment-naïve CD patients expressed higher levels of activating KIR as well as other non-KIR activating receptors vis-à-vis healthy controls.
They also showed increased frequencies of the cells expressing these receptors.
The expression of several KIR and non-KIR inhibitory receptors tended to decrease compared with the cells from healthy donors.
NK cells from the patients also expressed increased levels of different gut-homing integrin molecules and showed a history of increased recent degranulation events both constitutively and in response to their in vitro stimulation.
Furthermore, treatment of the patients tended to reverse these NK cell changes.
Our results demonstrate unequivocally, for the first time, that peripheral blood NK cells in treatment-naïve CD patients are more activated and are more poised to migrate to the gut compared to their counterpart cells from healthy individuals.
Moreover, they show that treatment of the patients tends to normalize their NK cells.
The results suggest that NK cells are very likely to play a role in the immunopathogenesis of Crohn disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Samarani, Suzanne& Sagala, Patrick& Jantchou, Prevost& Grimard, Guy& Faure, Christophe& Deslandres, Colette…[et al.]. 2020. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Samarani, Suzanne…[et al.]. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients. Mediators of Inflammation No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1191894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Samarani, Suzanne& Sagala, Patrick& Jantchou, Prevost& Grimard, Guy& Faure, Christophe& Deslandres, Colette…[et al.]. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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