hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro

المؤلفون المشاركون

Yu, Weifeng
Chen, Yi
Tang, Dan
Zhu, Linjie
Yuan, Tianjie
Jiao, Yingfu
Yan, Hexin

المصدر

Mediators of Inflammation

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-30

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض

الملخص EN

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a protein involved in the regulation of RNA processing, cell metabolism, migration, proliferation, and apoptosis.

However, the effect of hnRNPA2/B1 on injured endothelial cells (ECs) remains unclear.

We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms.

LPS was used to induce EC injury, and the roles of hnRNPA2/B1 in EC barrier dysfunction and inflammatory responses were measured by testing endothelial permeability and the expression of inflammatory factors after the suppression and overexpression of hnRNPA2/B1.

To explore the underlying mechanism by which hnRNPA2/B1 regulates endothelial injury, we studied the VE-cadherin/β-catenin pathway and NF-κB activation in HUVECs.

The results showed that hnRNPA2/B1 was elevated in LPS-stimulated HUVECs.

Moreover, knockdown of hnRNPA2/B1 aggravated endothelial injury by increasing EC permeability and promoting the secretion of the inflammatory cytokines TNF-α, IL-1β, and IL-6.

Overexpression of hnRNPA2/B1 can reduce the permeability and inflammatory response of HUVEC stimulated by LPS in vitro, while increasing the expression of VE-Cadherin and β-catenin.

Furthermore, the suppression of hnRNPA2/B1 increased the LPS-induced NF-κB activation and reduced the VE-cadherin/β-catenin pathway.

Taken together, these results suggest that hnRNPA2/B1 can regulate LPS-induced EC damage through regulating the NF-κB and VE-cadherin/β-catenin pathways.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Yi& Tang, Dan& Zhu, Linjie& Yuan, Tianjie& Jiao, Yingfu& Yan, Hexin…[et al.]. 2020. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191908

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Yi…[et al.]. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191908

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Yi& Tang, Dan& Zhu, Linjie& Yuan, Tianjie& Jiao, Yingfu& Yan, Hexin…[et al.]. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191908

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1191908