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hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro
المؤلفون المشاركون
Yu, Weifeng
Chen, Yi
Tang, Dan
Zhu, Linjie
Yuan, Tianjie
Jiao, Yingfu
Yan, Hexin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a protein involved in the regulation of RNA processing, cell metabolism, migration, proliferation, and apoptosis.
However, the effect of hnRNPA2/B1 on injured endothelial cells (ECs) remains unclear.
We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms.
LPS was used to induce EC injury, and the roles of hnRNPA2/B1 in EC barrier dysfunction and inflammatory responses were measured by testing endothelial permeability and the expression of inflammatory factors after the suppression and overexpression of hnRNPA2/B1.
To explore the underlying mechanism by which hnRNPA2/B1 regulates endothelial injury, we studied the VE-cadherin/β-catenin pathway and NF-κB activation in HUVECs.
The results showed that hnRNPA2/B1 was elevated in LPS-stimulated HUVECs.
Moreover, knockdown of hnRNPA2/B1 aggravated endothelial injury by increasing EC permeability and promoting the secretion of the inflammatory cytokines TNF-α, IL-1β, and IL-6.
Overexpression of hnRNPA2/B1 can reduce the permeability and inflammatory response of HUVEC stimulated by LPS in vitro, while increasing the expression of VE-Cadherin and β-catenin.
Furthermore, the suppression of hnRNPA2/B1 increased the LPS-induced NF-κB activation and reduced the VE-cadherin/β-catenin pathway.
Taken together, these results suggest that hnRNPA2/B1 can regulate LPS-induced EC damage through regulating the NF-κB and VE-cadherin/β-catenin pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yi& Tang, Dan& Zhu, Linjie& Yuan, Tianjie& Jiao, Yingfu& Yan, Hexin…[et al.]. 2020. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191908
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yi…[et al.]. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191908
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yi& Tang, Dan& Zhu, Linjie& Yuan, Tianjie& Jiao, Yingfu& Yan, Hexin…[et al.]. hnRNPA2B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherinβ-Catenin Signaling Modulation In Vitro. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191908
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191908
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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