Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study
المؤلفون المشاركون
Orsi, Nicolas M.
Mathew, Bipin
Obadofin, Omobolade
Rotimi, O.
Banjo, A.
Badmos, Kabir Bolarinwa
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
In Blacks, malignant melanoma (MM) is associated with greater morbidity and mortality compared to Caucasians.
MMs with BRAF V600E mutation as well as those with loss of p16 protein expression are associated with aggressive behavior and worse prognosis.
Objectives.
We determined BRAF (V600E) mutation status and loss of p16 expression in MM cases in Lagos, Nigeria, and correlated these with histopathologic parameters and patients’ age.
Methods.
Forty-five cases of MM received between January 2005 and December 2014 in the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital were subjected to immunohistochemical studies to determine BRAF V600E mutation and p16 protein expression.
These included cutaneous (n=37), musosal (n=3), and ocular MM (n=2) as well as lymph node metastatases (n=3).
Results.
BRAF (V600E) mutations were detected in 5/45 (11%) while 31/45 (69%) of the cases had loss of p16 expression.
No statistically significant association was found between the BRAF (V600E) mutation, loss of p16 expression, and histologic parameters such as histologic variant, Clark level, Breslow thickness, and ulceration.
Conclusion.
BRAF (V600E) mutation was detected only in a small proportion of cases while loss of p16 expression occurred in most cases which also had high Clark level, high Breslow thickness, and ulceration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Obadofin, Omobolade& Badmos, Kabir Bolarinwa& Orsi, Nicolas M.& Mathew, Bipin& Rotimi, O.& Banjo, A.. 2019. Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study. Journal of Skin Cancer،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1191915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Obadofin, Omobolade…[et al.]. Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study. Journal of Skin Cancer No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1191915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Obadofin, Omobolade& Badmos, Kabir Bolarinwa& Orsi, Nicolas M.& Mathew, Bipin& Rotimi, O.& Banjo, A.. Immunohistochemical Analysis of BRAF (V600E) Mutation and P16 Expression in Malignant Melanoma in Lagos, Nigeria: A 10-Year Retrospective Study. Journal of Skin Cancer. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1191915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر