Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients
المؤلفون المشاركون
Kotlega, Dariusz
Zembron-Lacny, Agnieszka
Morawin, Barbara
Golab-Janowska, Monika
Nowacki, Przemyslaw
Szczuko, Malgorzata
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
The neurotrophin brain-derived neurotrophic factor (BDNF) affects poststroke functional outcome, neurogenesis, neuroprotection, and neuroplasticity.
Its level is related to the diet and nutritional status, and more specifically, it is free fatty acids (FFAs) and eicosanoids that can have an impact on the BDNF level.
The aim of this study was to analyze the potential impact of FFAs and eicosanoids on the BDNF level in stroke patients.
Material and Methods.
Seventy-three ischemic stroke patients were prospectively enrolled in the study.
Laboratory tests were performed in all subjects, including the levels of FFAs, eicosanoids, and BDNF.
FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography, while BDNF was evaluated by the immune-enzymatic method (ELISA).
Results.
The plasma level of BDNF negatively correlated with C22:1n9 13 erucic acid, C18:3n3 linolenic acid (ALA), and lipoxin A4 15-epi-LxA4.
A direct association was observed in relation to BDNF and C16:1 palmitoleic acid and C20:3n6 eicosatrienoic acid (dihomo-gamma-linolenic acid (DGLA)).
Conclusions.
Saturated fatty acids and omega-3 and omega-9 erucic acids can affect signaling in the BDNF synthesis resulting in the decrease in BDNF.
There is a beneficial effect of DGLA on the BDNF level, while the effect of ALA on BDNF can be inhibitory.
Specialized proresolving lipid mediators can play a role in the BDNF metabolism.
BDNF can interact with inflammation as the risk factor in the cardiovascular disorders, including stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kotlega, Dariusz& Zembron-Lacny, Agnieszka& Morawin, Barbara& Golab-Janowska, Monika& Nowacki, Przemyslaw& Szczuko, Malgorzata. 2020. Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kotlega, Dariusz…[et al.]. Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kotlega, Dariusz& Zembron-Lacny, Agnieszka& Morawin, Barbara& Golab-Janowska, Monika& Nowacki, Przemyslaw& Szczuko, Malgorzata. Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر