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Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State
المؤلفون المشاركون
Yan, Jinchuan
Wang, Zhongqun
Bao, Zhengyang
Zhang, Lili
Li, Lihua
Pang, Qiwen
Sun, Zhen
Geng, Yue
Jing, Lele
Shao, Chen
Dai, Zhiyin
Wang, Xiaodong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Advanced glycation end products play an important role in diabetic atherosclerosis.
The effects of advanced glycation end products (AGEs) on vascular smooth muscle cell- (VSMC-) derived foam cell formation and phenotypic transformation are unknown.
Methods.
Serological and histological samples were obtained from diabetic amputation patients and accident amputation patients from the Affiliated Hospital of Jiangsu University.
CD68/Actin Alpha 2 (ACTA2) coimmunofluorescence sections were used to quantify the number of VSMCs with macrophage-like phenotypes.
Western blotting was used to detect the expression of the receptor of advanced glycation end products in vascular samples.
Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the level of serum Nε-carboxymethyl-lysine (CML).
In vitro oil red O staining was used to examine lipid accumulation in VSMCs stimulated by CML.
The expression of VSMCs and macrophage markers was measured by western blotting and quantitative real-time PCR.
Furthermore, changes in VSMC migration and secretion were detected by the Transwell assay and ELISA.
Results.
In the arterial plaque sections of diabetic patients, VSMCs transformed to a macrophage-like phenotype.
The serum CML and RAGE levels in the plaques were significantly higher in the diabetes group than those in the healthy control group and were significantly related to the number of macrophage-like VSMCs.
CML stimulation promoted intracellular lipid accumulation.
However, CML stimulation decreased the expression of VSMC markers and increased the expression of macrophage phenotype markers.
Finally, CML promoted smooth muscle cell migration and the secretion of proinflammatory-related factors.
Conclusions.
CML induces VSMC-derived foam cell formation, and VSMCs transdifferentiate to a macrophage-like state, which may be mediated by the activation of RAGE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bao, Zhengyang& Li, Lihua& Geng, Yue& Yan, Jinchuan& Dai, Zhiyin& Shao, Chen…[et al.]. 2020. Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bao, Zhengyang…[et al.]. Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bao, Zhengyang& Li, Lihua& Geng, Yue& Yan, Jinchuan& Dai, Zhiyin& Shao, Chen…[et al.]. Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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