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Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α
المؤلفون المشاركون
Ping, Fan
Li, Yu-xiu
Liu, Yiwen
Yu, Jie
Xu, Lingling
He, Shuli
Sun, Qi
Liu, Haibin
Li, Pingping
Ma, Chunxiao
Ma, Minglei
Lv, Lu
Zhang, Huabing
Li, Wei
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives.
In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL).
Designs.
The current cross-sectional analysis was based on data collected within a type 2 diabetes project.
Settings.
Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL).
However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting.
Participants.
This cross-sectional analysis included 467 participants (34.8% men).
Measurements.
Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured.
Detailed dietary data were obtained using a 24 h food recall.
LTL was assessed using a real-time PCR assay.
Regression models and simple regulatory models were used for data analysis.
Results.
There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55.
Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) α, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006).
Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31–5.36; P=0.003) and 1.98 (95% CI: 1.09–3.59; P=0.008).
There was a direct negative effect of dietary magnesium intake on LTL (B=−0.002; P=0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005).
Conclusions.
Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Jie& Liu, Haibin& He, Shuli& Li, Pingping& Ma, Chunxiao& Ma, Minglei…[et al.]. 2020. Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Jie…[et al.]. Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α. Mediators of Inflammation No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1191981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Jie& Liu, Haibin& He, Shuli& Li, Pingping& Ma, Chunxiao& Ma, Minglei…[et al.]. Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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